pubmed.ncbi.nlm.nih.gov

Etiology of nongonococcal urethritis - PubMed

️Wed Jan 01 1975

Etiology of nongonococcal urethritis

K K Holmes et al. N Engl J Med. 1975.

Abstract

Chlamydia trachomatis was isolated from the urethra from 48 (42 per cent) of 113 men with non-gonococcal urethritis (NGU), four (7 per cent) of 58 without overt urethritis, and 13 (19 per cent) of 69 with gonorrhea. Postgonococcal urethritis (PGU) developed in 11 of 11 men who had C. trum antibody to C. trachomatisis developed. The immunotype specificity of chlamydial antibody corresponded to the immunotype isolated. Among culture-negative patients. chlamydial antibody prevalence correlated with the number of past sex partners and with previous NGU. Herpesvirus hominis, cytomegalovirus, T-mycoplasma, Mycoplasma hominis, other bacteria, and Trichomonas vaginalis were not implicated in NGU or PGU. Thus, the cause of chlamydia-negative NGU and PGU remains obscure. Endocervical chlamydia were found in sex partners of 15 of 22 NGU patients with and two of 24 without urethral chlamydial infection (p smaller than 0.001). Tetracycline treatment of both sex partners appears advisable.

PIP: Chlamydia trachomartis was isolated from the urethra from 48 (42%) of 113 men with nongonococcal uethritis (NGU), 4 (7%) of 58 without overt urethritis, and 13 (19%) of 69 with gonorrhea. Postonococcal urethritis (PGU) developed in 11 of 11 men who had C. trachomatis. In 9 of 17 culture-positive seronegative patients with NGU or PGU, serum antibody to C. trachomatis developed. The immunotype specificity of chlamydial antibody corresponded to the immunotype isolated. Among culture-negative patients, chlamydial antibody prevalence correlated with the number of past sex partners and with previous NGU. Herpesvirus hominis, cytomegalovirus, T-mycoplasma, mycolpasma hominis, other bacteria, and Trichomanas vaginalis were not implicated in NGU or PGU. Thus, the cause of chlamydia-negative NGU and PGU remains obscure. Endocervical chlamydia were found in sex partners of 15 of 22 NGU patients with and 2 of 24 without urethral chlamydial infection (p0.001). Tetracycline treatment of both sex partners appears advisable.

PubMed Disclaimer

Cited by

Comparison of Chlamydia subgroup A detection from clinical specimens after 40 and 64 hours of incubation in 5-iodo-2-deoxyuridine-treated McCoy's cells.
Jonhson JE, Smith TF. Jonhson JE, et al. J Clin Microbiol. 1976 Mar;3(3):334-8. doi: 10.1128/jcm.3.3.334-338.1976. J Clin Microbiol. 1976. PMID: 57968 Free PMC article.
A forgotten factor in pelvic inflammatory disease: infection in the male partner.
Jacob M, Shahmanesh M, Whatley J, Thin N. Jacob M, et al. Br Med J (Clin Res Ed). 1987 Apr 4;294(6576):869. doi: 10.1136/bmj.294.6576.869. Br Med J (Clin Res Ed). 1987. PMID: 3105781 Free PMC article. No abstract available.
Nongonococcal urethritis: diagnosis and management.
Lucas LM, Smith DL. Lucas LM, et al. J Gen Intern Med. 1987 May-Jun;2(3):199-203. doi: 10.1007/BF02596152. J Gen Intern Med. 1987. PMID: 3295152 Review. No abstract available.
Infection and pyospermia in male infertility.
Bar-Chama N, Fisch H. Bar-Chama N, et al. World J Urol. 1993;11(2):76-81. doi: 10.1007/BF00182033. World J Urol. 1993. PMID: 8343798 Review.
Evidence of Chlamydia trachomatis infection in sexually acquired reactive arthritis.
Keat AC, Thomas BJ, Taylor-Robinson D, Pegrum GD, Maini RN, Scott JT. Keat AC, et al. Ann Rheum Dis. 1980 Oct;39(5):431-7. doi: 10.1136/ard.39.5.431. Ann Rheum Dis. 1980. PMID: 6893652 Free PMC article.

Etiology of nongonococcal urethritis - PubMed