Physiological role of the putative ammonium transporter RhCG in the mouse - PubMed

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• PMID: 16564721
• DOI: 10.1016/j.tracli.2006.03.003

Review

Physiological role of the putative ammonium transporter RhCG in the mouse

S Biver et al. Transfus Clin Biol. 2006 Mar-Apr.

Abstract

Ammonium excretion into urine is a major process essential to the regulation of acid-base homeostasis. We have shown that Rh-type proteins, including renal RhCG, belong to the Mep/Amt family of ammonium transporters and promote bi-directional ammonium transport upon heterologous expression in yeast. To study the physiological role of RhCG and to test a potential function in ammonium excretion, we have generated mice bearing an invalidation of the corresponding gene.

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