Genetics and genomics of core short tandem repeat loci used in human identity testing - PubMed

Review

Genetics and genomics of core short tandem repeat loci used in human identity testing

John M Butler. J Forensic Sci. 2006 Mar.

Abstract

Over the past decade, the human identity testing community has settled on a set of core short tandem repeat (STR) loci that are widely used for DNA typing applications. A variety of commercial kits enable robust amplification of these core STR loci. A brief history is presented regarding the selection of core autosomal and Y-chromosomal STR markers. The physical location of each STR locus in the human genome is delineated and allele ranges and variants observed in human populations are summarized as are mutation rates observed from parentage testing. Internet resources for additional information on core STR loci are reviewed. Additional topics are also discussed, including potential linkage of STR loci to genetic disease-causing genes, probabilistic predictions of sample ethnicity, and desirable characteristics for additional STR loci that may be added in the future to the current core loci. These core STR loci, which form the basis for DNA databases worldwide, will continue to play an important role in forensic science for many years to come.

Similar articles

• [STR loci D2S1338 and D19S433 in a population sample from the Lower Silesia region].

  Krzyzanńska A, Kowalczyk E, Markowska J, Dobosz T. Krzyzanńska A, et al. Arch Med Sadowej Kryminol. 2006 Oct-Dec;56(4):236-8. Arch Med Sadowej Kryminol. 2006. PMID: 17249371 Polish.

• Comprehensive annotated STR physical map of the human Y chromosome: Forensic implications.

  Hanson EK, Ballantyne J. Hanson EK, et al. Leg Med (Tokyo). 2006 Mar;8(2):110-20. doi: 10.1016/j.legalmed.2005.10.001. Epub 2005 Dec 7. Leg Med (Tokyo). 2006. PMID: 16337821

• The utility of short tandem repeat loci beyond human identification: implications for development of new DNA typing systems.

  Chakraborty R, Stivers DN, Su B, Zhong Y, Budowle B. Chakraborty R, et al. Electrophoresis. 1999 Jun;20(8):1682-96. doi: 10.1002/(SICI)1522-2683(19990101)20:8<1682::AID-ELPS1682>3.0.CO;2-Z. Electrophoresis. 1999. PMID: 10435432 Review.

• Short tandem repeat-based identification of individuals and parents.

  Tracey M. Tracey M. Croat Med J. 2001 Jun;42(3):233-8. Croat Med J. 2001. PMID: 11387629 Review.

Cited by

• Beyond STRs: The Role of Diallelic Markers in Forensic Genetics.

  Schneider PM. Schneider PM. Transfus Med Hemother. 2012 Jun;39(3):176-180. doi: 10.1159/000339139. Epub 2012 May 15. Transfus Med Hemother. 2012. PMID: 22851932 Free PMC article.

• STRs vs. SNPs: thoughts on the future of forensic DNA testing.

  Butler JM, Coble MD, Vallone PM. Butler JM, et al. Forensic Sci Med Pathol. 2007 Sep;3(3):200-5. doi: 10.1007/s12024-007-0018-1. Epub 2007 Sep 12. Forensic Sci Med Pathol. 2007. PMID: 25869164

• The tooth for molecular analysis and identification : a forensic approach.

  Corte-Real A, Anjos MJ, Vieira DM, Gamero JJ. Corte-Real A, et al. J Forensic Odontostomatol. 2012 Jul 1;30(1):22-8. J Forensic Odontostomatol. 2012. PMID: 23000808 Free PMC article.

• Sangiovese and its offspring in southern Italy.

  Gasparro M, Caputo AR, Bergamini C, Crupi P, Cardone MF, Perniola R, Antonacci D. Gasparro M, et al. Mol Biotechnol. 2013 Jun;54(2):581-9. doi: 10.1007/s12033-012-9600-1. Mol Biotechnol. 2013. PMID: 23001829

• An efficient identification strategy of clonal tea cultivars using long-core motif SSR markers.

  Wang RJ, Gao XF, Kong XR, Yang J. Wang RJ, et al. Springerplus. 2016 Jul 22;5(1):1152. doi: 10.1186/s40064-016-2835-8. eCollection 2016. Springerplus. 2016. PMID: 27504250 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal