Retinoid signaling determines germ cell fate in mice - PubMed

Affiliations

• PMID: 16574820
• DOI: 10.1126/science.1125691

Retinoid signaling determines germ cell fate in mice

Josephine Bowles et al. Science. 2006.

Abstract

Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and initiate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes of Cyp26b1-knockout mouse embryos, germ cells enter meiosis precociously, as if in a normal ovary. Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.

Similar articles

• FGF9 suppresses meiosis and promotes male germ cell fate in mice.

  Bowles J, Feng CW, Spiller C, Davidson TL, Jackson A, Koopman P. Bowles J, et al. Dev Cell. 2010 Sep 14;19(3):440-9. doi: 10.1016/j.devcel.2010.08.010. Dev Cell. 2010. PMID: 20833365

• Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad.

  Childs AJ, Cowan G, Kinnell HL, Anderson RA, Saunders PT. Childs AJ, et al. PLoS One. 2011;6(6):e20249. doi: 10.1371/journal.pone.0020249. Epub 2011 Jun 3. PLoS One. 2011. PMID: 21674038 Free PMC article.

• New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice.

  Guerquin MJ, Duquenne C, Lahaye JB, Tourpin S, Habert R, Livera G. Guerquin MJ, et al. Dev Biol. 2010 Oct 15;346(2):320-30. doi: 10.1016/j.ydbio.2010.08.002. Epub 2010 Aug 11. Dev Biol. 2010. PMID: 20707993

• Sex determination in mammalian germ cells: extrinsic versus intrinsic factors.

  Bowles J, Koopman P. Bowles J, et al. Reproduction. 2010 Jun;139(6):943-58. doi: 10.1530/REP-10-0075. Epub 2010 Apr 15. Reproduction. 2010. PMID: 20395427 Review.

• Germ Cell Commitment to Oogenic Versus Spermatogenic Pathway: The Role of Retinoic Acid.

  Agrimson KS, Hogarth CA. Agrimson KS, et al. Results Probl Cell Differ. 2016;58:135-66. doi: 10.1007/978-3-319-31973-5_6. Results Probl Cell Differ. 2016. PMID: 27300178 Review.

Cited by

• RA induces differentiation of multipotent P19 cells towards male germ cell.

  Zhang L, Tang J, Haines CJ, Feng H, Teng X, Han Y. Zhang L, et al. In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):85-91. doi: 10.1007/s11626-014-9746-1. Epub 2014 Dec 24. In Vitro Cell Dev Biol Anim. 2015. PMID: 25537091

• Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells.

  Wu Q, Kanata K, Saba R, Deng CX, Hamada H, Saga Y. Wu Q, et al. Development. 2013 Jan 15;140(2):291-300. doi: 10.1242/dev.087882. Epub 2012 Dec 5. Development. 2013. PMID: 23221368 Free PMC article.

• Identification and Expression Pattern of cyp26b1 Gene in Gonad of the Chinese Tongue Sole (Cynoglossus semilaevis).

  Cui Z, Wang J, Yang Y, Chen Z, Wang Q, Wang J, Zhang T, Xu W, Chen S. Cui Z, et al. Animals (Basel). 2022 Oct 2;12(19):2652. doi: 10.3390/ani12192652. Animals (Basel). 2022. PMID: 36230393 Free PMC article.

• SOX9 in organogenesis: shared and unique transcriptional functions.

  Ming Z, Vining B, Bagheri-Fam S, Harley V. Ming Z, et al. Cell Mol Life Sci. 2022 Sep 17;79(10):522. doi: 10.1007/s00018-022-04543-4. Cell Mol Life Sci. 2022. PMID: 36114905 Free PMC article. Review.

• Juvenile hormones direct primordial germ cell migration to the embryonic gonad.

  Barton LJ, Sanny J, Packard Dawson E, Nouzova M, Noriega FG, Stadtfeld M, Lehmann R. Barton LJ, et al. Curr Biol. 2024 Feb 5;34(3):505-518.e6. doi: 10.1016/j.cub.2023.12.033. Epub 2024 Jan 11. Curr Biol. 2024. PMID: 38215744 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)