Transcription from a TATA-less promoter requires a multisubunit TFIID complex - PubMed

Affiliations

• PMID: 1657708
• DOI: 10.1101/gad.5.11.1935

Free article

Transcription from a TATA-less promoter requires a multisubunit TFIID complex

B F Pugh et al. Genes Dev. 1991 Nov.

Free article

Abstract

In eukaryotes, the TATA box-binding protein (TBP) is responsible for nucleating assembly of the transcription initiation machinery. Here, we report that a TFIID complex containing TBP is essential for transcription even at a promoter that lacks a TATA box. Immunopurification of TFIID reveals that the active species in reconstituting TATA-less transcription is a multisubunit complex consisting of TBP and many TBP-associated factors (TAFs).

Similar articles

• Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.

  Zhou Q, Lieberman PM, Boyer TG, Berk AJ. Zhou Q, et al. Genes Dev. 1992 Oct;6(10):1964-74. doi: 10.1101/gad.6.10.1964. Genes Dev. 1992. PMID: 1398073

• Core promoter-specific function of a mutant transcription factor TFIID defective in TATA-box binding.

  Martinez E, Zhou Q, L'Etoile ND, Oelgeschläger T, Berk AJ, Roeder RG. Martinez E, et al. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11864-8. doi: 10.1073/pnas.92.25.11864. Proc Natl Acad Sci U S A. 1995. PMID: 8524864 Free PMC article.

• Mechanisms of transcriptional activation and repression can both involve TFIID.

  Manley JL, Um M, Li C, Ashali H. Manley JL, et al. Philos Trans R Soc Lond B Biol Sci. 1996 Apr 29;351(1339):517-26. doi: 10.1098/rstb.1996.0050. Philos Trans R Soc Lond B Biol Sci. 1996. PMID: 8735274 Review.

• Biochemistry and structural biology of transcription factor IID (TFIID).

  Burley SK, Roeder RG. Burley SK, et al. Annu Rev Biochem. 1996;65:769-99. doi: 10.1146/annurev.bi.65.070196.004005. Annu Rev Biochem. 1996. PMID: 8811195 Review.

Cited by

• Transcription initiation by human RNA polymerase II visualized at single-molecule resolution.

  Revyakin A, Zhang Z, Coleman RA, Li Y, Inouye C, Lucas JK, Park SR, Chu S, Tjian R. Revyakin A, et al. Genes Dev. 2012 Aug 1;26(15):1691-702. doi: 10.1101/gad.194936.112. Epub 2012 Jul 18. Genes Dev. 2012. PMID: 22810624 Free PMC article.

• A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo.

  Scofield MD, Tapper AR, Gardner PD. Scofield MD, et al. Neuroscience. 2010 Nov 10;170(4):1056-64. doi: 10.1016/j.neuroscience.2010.08.007. Epub 2010 Aug 6. Neuroscience. 2010. PMID: 20696214 Free PMC article.

• Human telomerase and its regulation.

  Cong YS, Wright WE, Shay JW. Cong YS, et al. Microbiol Mol Biol Rev. 2002 Sep;66(3):407-25, table of contents. doi: 10.1128/MMBR.66.3.407-425.2002. Microbiol Mol Biol Rev. 2002. PMID: 12208997 Free PMC article. Review.

• Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death.

  Liu K, Paterson AJ, Chin E, Kudlow JE. Liu K, et al. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2820-5. doi: 10.1073/pnas.97.6.2820. Proc Natl Acad Sci U S A. 2000. PMID: 10717000 Free PMC article.

• An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene.

  Russek SJ, Bandyopadhyay S, Farb DH. Russek SJ, et al. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8600-5. doi: 10.1073/pnas.97.15.8600. Proc Natl Acad Sci U S A. 2000. PMID: 10900018 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • HighWire

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • FlyBase