The ubiquitin-mediated system for intracellular protein degradation - PubMed
Review
The ubiquitin-mediated system for intracellular protein degradation
A Ciechanover. J Basic Clin Physiol Pharmacol. 1991 Jul-Sep.
Abstract
Degradation of proteins by the ubiquitin system involves several discrete steps. Initially, multiple molecules of ubiquitin are covalently conjugated to the target substrate in an energy-requiring reaction. The protein thus marked is degraded by a specific ATP-dependent protease, and free and reutilizable ubiquitin is released. In this review we discuss the mechanisms involved in ubiquitin activation, selection of substrates for conjugation, and subsequent degradation of ubiquitin-conjugated proteins in the cell-free system. In addition, we summarize briefly what is currently known of the physiological roles of the ubiquitin system in vivo.
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