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A pericellular collagenase directs the 3-dimensional development of white adipose tissue - PubMed

  • ️Sun Jan 01 2006

. 2006 May 5;125(3):577-91.

doi: 10.1016/j.cell.2006.02.050.

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A pericellular collagenase directs the 3-dimensional development of white adipose tissue

Tae-Hwa Chun et al. Cell. 2006.

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Abstract

White adipose tissue (WAT) serves as the primary energy depot in the body by storing fat. During development, fat cell precursors (i.e., preadipocytes) undergo a hypertrophic response as they mature into lipid-laden adipocytes. However, the mechanisms that regulate adipocyte size and mass remain undefined. Herein, we demonstrate that the membrane-anchored metalloproteinase, MT1-MMP, coordinates adipocyte differentiation in vivo. In the absence of the protease, WAT development is aborted, leaving tissues populated by mini-adipocytes which render null mice lipodystrophic. While MT1-MMP preadipocytes display a cell autonomous defect in vivo, null progenitors retain the ability to differentiate into functional adipocytes during 2-dimensional (2-D) culture. By contrast, within the context of the 3-dimensional (3-D) ECM, normal adipocyte maturation requires a burst in MT1-MMP-mediated proteolysis that modulates pericellular collagen rigidity in a fashion that controls adipogenesis. Hence, MT1-MMP acts as a 3-D-specific adipogenic factor that directs the dynamic adipocyte-ECM interactions critical to WAT development.

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Comment in

  • Forcing the third dimension.

    Boudreau N, Weaver V. Boudreau N, et al. Cell. 2006 May 5;125(3):429-31. doi: 10.1016/j.cell.2006.04.019. Cell. 2006. PMID: 16678088 Review.

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