The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer - PubMed

Affiliations

• PMID: 16855786
• DOI: 10.1007/s10735-006-9042-9

Review

The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

Michael Zeidler et al. J Mol Histol. 2006 Sep.

Abstract

The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.

Similar articles

• EZH2 and cancer stem cells: fact or fiction?

  Crea F. Crea F. Epigenomics. 2011 Apr;3(2):127-8. doi: 10.2217/epi.11.4. Epigenomics. 2011. PMID: 22122274 No abstract available.

• EZH2 methyltransferase and H3K27 methylation in breast cancer.

  Yoo KH, Hennighausen L. Yoo KH, et al. Int J Biol Sci. 2012;8(1):59-65. doi: 10.7150/ijbs.8.59. Epub 2011 Nov 18. Int J Biol Sci. 2012. PMID: 22211105 Free PMC article. Review.

• EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.

  Hwang C, Giri VN, Wilkinson JC, Wright CW, Wilkinson AS, Cooney KA, Duckett CS. Hwang C, et al. Breast Cancer Res Treat. 2008 Jan;107(2):235-42. doi: 10.1007/s10549-007-9542-7. Epub 2007 Apr 24. Breast Cancer Res Treat. 2008. PMID: 17453341

• The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells.

  Zeidler M, Varambally S, Cao Q, Chinnaiyan AM, Ferguson DO, Merajver SD, Kleer CG. Zeidler M, et al. Neoplasia. 2005 Nov;7(11):1011-9. doi: 10.1593/neo.05472. Neoplasia. 2005. PMID: 16331887 Free PMC article.

• [Recent advances on EZH2 in malignant tumors].

  Li J, Fan QH. Li J, et al. Zhonghua Bing Li Xue Za Zhi. 2009 Dec;38(12):856-8. Zhonghua Bing Li Xue Za Zhi. 2009. PMID: 20193471 Review. Chinese. No abstract available.

Cited by

• Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression.

  Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R. Grzenda A, et al. Epigenetics Chromatin. 2013 Feb 28;6(1):3. doi: 10.1186/1756-8935-6-3. Epigenetics Chromatin. 2013. PMID: 23448518 Free PMC article.

• A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.

  Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A. Hong Z, et al. Nucleic Acids Res. 2008 May;36(9):2939-47. doi: 10.1093/nar/gkn146. Epub 2008 Apr 1. Nucleic Acids Res. 2008. PMID: 18385154 Free PMC article.

• Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients.

  Çıldır ÖŞ, Özmen Ö, Kul S, Rişvanlı A, Özalp G, Sabuncu A, Kul O. Çıldır ÖŞ, et al. Vet Med Sci. 2024 May;10(3):e1366. doi: 10.1002/vms3.1366. Vet Med Sci. 2024. PMID: 38527110 Free PMC article.

• Ezh2, a novel target in detection and therapy of breast cancer.

  Pourakbar S, Pluard TJ, Accurso AD, Farassati F. Pourakbar S, et al. Onco Targets Ther. 2017 May 22;10:2685-2687. doi: 10.2147/OTT.S138777. eCollection 2017. Onco Targets Ther. 2017. PMID: 28579806 Free PMC article. No abstract available.

• Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids.

  Yang Q, Laknaur A, Elam L, Ismail N, Gavrilova-Jordan L, Lue J, Diamond MP, Al-Hendy A. Yang Q, et al. Reprod Sci. 2016 Oct;23(10):1314-25. doi: 10.1177/1933719116638186. Epub 2016 Mar 31. Reprod Sci. 2016. PMID: 27036951 Free PMC article.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Medical

  • MedlinePlus Health Information