Odortypes and MHC peptides: Complementary chemosignals of MHC haplotype? - PubMed

Review

Odortypes and MHC peptides: Complementary chemosignals of MHC haplotype?

Diego Restrepo et al. Trends Neurosci. 2006 Nov.

Abstract

The olfactory and immune systems must perform optimally in the task of recognizing thousands of molecules to ensure survival. A particularly intriguing link between these systems is that animals can smell differences in the major histocompatibility complex (MHC), a cluster of highly polymorphic genes found on human chromosome 6 and mouse chromosome 17. Two different sets of compounds found in urine have been postulated to convey information on MHC haplotype: volatile compounds (odortypes) and MHC peptides. Here we argue for complementary roles for these chemosignals.

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