Principles of diffusion tensor imaging and its applications to basic neuroscience research - PubMed

Affiliations

• PMID: 16950152
• DOI: 10.1016/j.neuron.2006.08.012

Free article

Review

Principles of diffusion tensor imaging and its applications to basic neuroscience research

Susumu Mori et al. Neuron. 2006.

Free article

Abstract

The brain contains more than 100 billion neurons that communicate with each other via axons for the formation of complex neural networks. The structural mapping of such networks during health and disease states is essential for understanding brain function. However, our understanding of brain structural connectivity is surprisingly limited, due in part to the lack of noninvasive methodologies to study axonal anatomy. Diffusion tensor imaging (DTI) is a recently developed MRI technique that can measure macroscopic axonal organization in nervous system tissues. In this article, the principles of DTI methodologies are explained, and several applications introduced, including visualization of axonal tracts in myelin and axonal injuries as well as human brain and mouse embryonic development. The strengths and limitations of DTI and key areas for future research and development are also discussed.

Similar articles

• Magnetic resonance imaging of functional anatomy: use for small animal epilepsy models.

  Obenaus A, Jacobs RE. Obenaus A, et al. Epilepsia. 2007;48 Suppl 4:11-7. doi: 10.1111/j.1528-1167.2007.01237.x. Epilepsia. 2007. PMID: 17767571 Review.

• [Visualization of neuronal fiber tracts in white matter based on diffusion tensor].

  Zhao X, Wang M, Gao W, Liu H. Zhao X, et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Aug;23(4):899-902. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006. PMID: 17002134 Review. Chinese.

• Three-dimensional high-resolution diffusion tensor imaging and tractography of the developing rabbit brain.

  D'Arceuil H, Liu C, Levitt P, Thompson B, Kosofsky B, de Crespigny A. D'Arceuil H, et al. Dev Neurosci. 2008;30(4):262-75. doi: 10.1159/000110503. Epub 2007 Oct 26. Dev Neurosci. 2008. PMID: 17962716

• Advanced MR imaging techniques and characterization of residual anatomy.

  Stroman PW, Bosma RL, Kornelsen J, Lawrence-Dewar J, Wheeler-Kingshott C, Cadotte D, Fehlings MG. Stroman PW, et al. Clin Neurol Neurosurg. 2012 Jun;114(5):460-70. doi: 10.1016/j.clineuro.2012.01.003. Epub 2012 Feb 11. Clin Neurol Neurosurg. 2012. PMID: 22326716 Review.

• Clinical applications of diffusion tensor imaging.

  Dong Q, Welsh RC, Chenevert TL, Carlos RC, Maly-Sundgren P, Gomez-Hassan DM, Mukherji SK. Dong Q, et al. J Magn Reson Imaging. 2004 Jan;19(1):6-18. doi: 10.1002/jmri.10424. J Magn Reson Imaging. 2004. PMID: 14696215 Review.

Cited by

• Fast diffusion tensor magnetic resonance imaging of the mouse brain at ultrahigh-field: aiming at cohort studies.

  Müller HP, Vernikouskaya I, Ludolph AC, Kassubek J, Rasche V. Müller HP, et al. PLoS One. 2012;7(12):e53389. doi: 10.1371/journal.pone.0053389. Epub 2012 Dec 28. PLoS One. 2012. PMID: 23285289 Free PMC article.

• Widespread changes in white matter microstructure after a day of waking and sleep deprivation.

  Elvsåshagen T, Norbom LB, Pedersen PØ, Quraishi SH, Bjørnerud A, Malt UF, Groote IR, Westlye LT. Elvsåshagen T, et al. PLoS One. 2015 May 28;10(5):e0127351. doi: 10.1371/journal.pone.0127351. eCollection 2015. PLoS One. 2015. PMID: 26020651 Free PMC article. Clinical Trial.

• Is diffusion tensor imaging useful in the assessment of the sciatic nerve and its pathologies? Our clinical experience.

  Bernabeu Á, López-Celada S, Alfaro A, Mas JJ, Sánchez-González J. Bernabeu Á, et al. Br J Radiol. 2016 Oct;89(1066):20150728. doi: 10.1259/bjr.20150728. Epub 2016 Jul 26. Br J Radiol. 2016. PMID: 27459247 Free PMC article.

• Diffusion Tensor Tractography of the Cerebellar Peduncles in Prematurely Born 7-Year-Old Children.

  Shany E, Inder TE, Goshen S, Lee I, Neil JJ, Smyser CD, Doyle LW, Anderson PJ, Shimony JS. Shany E, et al. Cerebellum. 2017 Apr;16(2):314-325. doi: 10.1007/s12311-016-0796-7. Cerebellum. 2017. PMID: 27255706 Free PMC article.

• Does prenatal stress alter the developing connectome?

  Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR. Scheinost D, et al. Pediatr Res. 2017 Jan;81(1-2):214-226. doi: 10.1038/pr.2016.197. Epub 2016 Sep 27. Pediatr Res. 2017. PMID: 27673421 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database