Percutaneous absorption of crotamiton in man following single and multiple dosing - PubMed
Clinical Trial
Percutaneous absorption of crotamiton in man following single and multiple dosing
E Dika et al. Cutan Ocul Toxicol. 2006.
Abstract
Purpose: Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin.
Methods: We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose regimen by measuring urinary excretion and liquid scintillation counting in three groups of four healthy volunteers. The Feldmann urinary excretion method was utilized to ascertain percutaneous absorption. Our results showed that tape stripping does not increase percutaneous absorption of crotamiton; upon repeated application.
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