Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure - PubMed

Affiliations

• PMID: 16991145
• DOI: 10.1002/mds.21096

Case Reports

Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure

Annu Aggarwal et al. Mov Disord. 2006 Nov.

Abstract

We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa-unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF.

Similar articles

• Brain metal concentrations in chronic liver failure patients with pallidal T1 MRI hyperintensity.

  Klos KJ, Ahlskog JE, Kumar N, Cambern S, Butz J, Burritt M, Fealey RD, Cowl CT, Parisi JE, Josephs KA. Klos KJ, et al. Neurology. 2006 Dec 12;67(11):1984-9. doi: 10.1212/01.wnl.0000247037.37807.76. Neurology. 2006. PMID: 17159105

• MPTP-Induced pallidal lesions in rhesus monkeys.

  Zhang Z, Zhang M, Ai Y, Avison C, Gash DM. Zhang Z, et al. Exp Neurol. 1999 Jan;155(1):140-9. doi: 10.1006/exnr.1998.6976. Exp Neurol. 1999. PMID: 9918713

• [A patient with parkinsonism presenting hyperintensity in the globus pallidus on T1-weighted MR images: the correlation with manganese poisoning].

  Katsuragi T, Takahashi T, Shibuya K, Nagatomo H, Iwabuchi K. Katsuragi T, et al. Rinsho Shinkeigaku. 1996 Jun;36(6):780-2. Rinsho Shinkeigaku. 1996. PMID: 8937201 Japanese.

• [A case of welder presenting with parkinsonism after chronic manganese exposure].

  Sato K, Ueyama H, Arakawa R, Kumamoto T, Tsuda T. Sato K, et al. Rinsho Shinkeigaku. 2000 Nov;40(11):1110-5. Rinsho Shinkeigaku. 2000. PMID: 11332192 Review. Japanese.

• [Manganism and parkinsonism].

  Kondo T. Kondo T. Ryoikibetsu Shokogun Shirizu. 1999;(27 Pt 2):41-4. Ryoikibetsu Shokogun Shirizu. 1999. PMID: 10434586 Review. Japanese. No abstract available.

Cited by

• Manganism in the 21st century: the Hanninen lecture.

  Racette BA. Racette BA. Neurotoxicology. 2014 Dec;45:201-7. doi: 10.1016/j.neuro.2013.09.007. Epub 2013 Oct 19. Neurotoxicology. 2014. PMID: 24148923 Free PMC article. Review.

• Manganese and Parkinson's disease: a critical review and new findings.

  Guilarte TR. Guilarte TR. Environ Health Perspect. 2010 Aug;118(8):1071-80. doi: 10.1289/ehp.0901748. Epub 2010 Apr 19. Environ Health Perspect. 2010. PMID: 20403794 Free PMC article. Review.

• Acquired hepatocerebral degeneration.

  Ferrara J, Jankovic J. Ferrara J, et al. J Neurol. 2009 Mar;256(3):320-32. doi: 10.1007/s00415-009-0144-7. Epub 2009 Feb 17. J Neurol. 2009. PMID: 19224314 Review.

• The role of the Golgi-resident SPCA Ca²⁺/Mn²⁺ pump in ionic homeostasis and neural function.

  He W, Hu Z. He W, et al. Neurochem Res. 2012 Mar;37(3):455-68. doi: 10.1007/s11064-011-0644-6. Epub 2011 Nov 15. Neurochem Res. 2012. PMID: 22083668 Review.

• Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates.

  Burton NC, Guilarte TR. Burton NC, et al. Environ Health Perspect. 2009 Mar;117(3):325-32. doi: 10.1289/ehp.0800035. Epub 2008 Oct 3. Environ Health Perspect. 2009. PMID: 19337503 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Medical

  • MedlinePlus Health Information