Neurobiology of schizophrenia - PubMed
- ️Sun Jan 01 2006
Review
. 2006 Oct 5;52(1):139-53.
doi: 10.1016/j.neuron.2006.09.015.
Affiliations
- PMID: 17015232
- DOI: 10.1016/j.neuron.2006.09.015
Free article
Review
Neurobiology of schizophrenia
Christopher A Ross et al. Neuron. 2006.
Free article
Abstract
With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia affects the most basic human processes of perception, emotion, and judgment. Evidence increasingly suggests that schizophrenia is a subtle disorder of brain development and plasticity. Genetic studies are beginning to identify proteins of candidate genetic risk factors for schizophrenia, including dysbindin, neuregulin 1, DAOA, COMT, and DISC1, and neurobiological studies of the normal and variant forms of these genes are now well justified. We suggest that DISC1 may offer especially valuable insights. Mechanistic studies of the properties of these candidate genes and their protein products should clarify the molecular, cellular, and systems-level pathogenesis of schizophrenia. This can help redefine the schizophrenia phenotype and shed light on the relationship between schizophrenia and other major psychiatric disorders. Understanding these basic pathologic processes may yield novel targets for the development of more effective treatments.
Similar articles
-
Owen MJ, Craddock N, O'Donovan MC. Owen MJ, et al. Trends Genet. 2005 Sep;21(9):518-25. doi: 10.1016/j.tig.2005.06.011. Trends Genet. 2005. PMID: 16009449 Review.
-
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence.
Harrison PJ, Weinberger DR. Harrison PJ, et al. Mol Psychiatry. 2005 Jan;10(1):40-68; image 5. doi: 10.1038/sj.mp.4001558. Mol Psychiatry. 2005. PMID: 15263907 Review.
-
Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses.
Sawamura N, Sawa A. Sawamura N, et al. Ann N Y Acad Sci. 2006 Nov;1086:126-33. doi: 10.1196/annals.1377.018. Ann N Y Acad Sci. 2006. PMID: 17185511 Review.
-
Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?
Scolnick EM, Petryshen T, Sklar P. Scolnick EM, et al. Harv Rev Psychiatry. 2006 Mar-Apr;14(2):64-77. doi: 10.1080/10673220600642960. Harv Rev Psychiatry. 2006. PMID: 16603473 Review.
-
Roffman JL, Weiss AP, Goff DC, Rauch SL, Weinberger DR. Roffman JL, et al. Harv Rev Psychiatry. 2006 Mar-Apr;14(2):78-91. doi: 10.1080/10673220600642945. Harv Rev Psychiatry. 2006. PMID: 16603474 Review.
Cited by
-
Goo BS, Mun DJ, Kim S, Nhung TTM, Lee SB, Woo Y, Kim SJ, Suh BK, Park SJ, Lee HE, Park K, Jang H, Rah JC, Yoon KJ, Baek ST, Park SY, Park SK. Goo BS, et al. Mol Psychiatry. 2023 Feb;28(2):856-870. doi: 10.1038/s41380-022-01856-5. Epub 2022 Nov 10. Mol Psychiatry. 2023. PMID: 36357673 Free PMC article.
-
Iptakalim attenuates self-administration and acquired goal-tracking behavior controlled by nicotine.
Charntikov S, Swalve N, Pittenger S, Fink K, Schepers S, Hadlock GC, Fleckenstein AE, Hu G, Li M, Bevins RA. Charntikov S, et al. Neuropharmacology. 2013 Dec;75:138-44. doi: 10.1016/j.neuropharm.2013.07.019. Epub 2013 Aug 2. Neuropharmacology. 2013. PMID: 23916479 Free PMC article.
-
Abazyan B, Dziedzic J, Hua K, Abazyan S, Yang C, Mori S, Pletnikov MV, Guilarte TR. Abazyan B, et al. Schizophr Bull. 2014 May;40(3):575-84. doi: 10.1093/schbul/sbt071. Epub 2013 May 28. Schizophr Bull. 2014. PMID: 23716713 Free PMC article.
-
Ge X, Frank CL, Calderon de Anda F, Tsai LH. Ge X, et al. Neuron. 2010 Jan 28;65(2):191-203. doi: 10.1016/j.neuron.2010.01.011. Neuron. 2010. PMID: 20152126 Free PMC article.
-
A new model of the disrupted latent inhibition in C57BL/6J mice after bupropion treatment.
Lipina T, Roder J. Lipina T, et al. Psychopharmacology (Berl). 2010 Feb;208(3):487-98. doi: 10.1007/s00213-009-1749-3. Epub 2009 Dec 16. Psychopharmacology (Berl). 2010. PMID: 20013111
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous