T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine - PubMed

T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine

James J Kobie et al. J Immunol. 2006.

Abstract

CD73 (5'-ectonucleotidase) is expressed by two distinct mouse CD4 T cell populations: CD25+ (FoxP3+) T regulatory (Treg) cells that suppress T cell proliferation but do not secrete IL-2, and CD25- uncommitted primed precursor Th (Thpp) cells that secrete IL-2 but do not suppress in standard Treg suppressor assays. CD73 on both Treg and Thpp cells converted extracellular 5'-AMP to adenosine. Adenosine suppressed proliferation and cytokine secretion of Th1 and Th2 effector cells, even when target cells were activated by anti-CD3 and anti-CD28. This represents an additional suppressive mechanism of Treg cells and a previously unrecognized suppressive activity of Thpp cells. Infiltration of either Treg or Thpp cells at inflammatory sites could potentially convert 5'-AMP generated by neutrophils or dying cells into the anti-inflammatory mediator adenosine, thus dampening excessive immune reactions.

Similar articles

• Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells.

  Romio M, Reinbeck B, Bongardt S, Hüls S, Burghoff S, Schrader J. Romio M, et al. Am J Physiol Cell Physiol. 2011 Aug;301(2):C530-9. doi: 10.1152/ajpcell.00385.2010. Epub 2011 May 18. Am J Physiol Cell Physiol. 2011. PMID: 21593451

• CD73 Expressed on γδ T Cells Shapes Their Regulatory Effect in Experimental Autoimmune Uveitis.

  Liang D, Zuo A, Zhao R, Shao H, Born WK, O'Brien RL, Kaplan HJ, Sun D. Liang D, et al. PLoS One. 2016 Feb 26;11(2):e0150078. doi: 10.1371/journal.pone.0150078. eCollection 2016. PLoS One. 2016. PMID: 26919582 Free PMC article.

• CD73 and Ly-6A/E distinguish in vivo primed but uncommitted mouse CD4 T cells from type 1 or type 2 effector cells.

  Yang L, Kobie JJ, Mosmann TR. Yang L, et al. J Immunol. 2005 Nov 15;175(10):6458-64. doi: 10.4049/jimmunol.175.10.6458. J Immunol. 2005. PMID: 16272299

• [Immune regulation via the generation of extracellular adenosine by CD73].

  Tsukamoto H. Tsukamoto H. Seikagaku. 2014 Dec;86(6):766-9. Seikagaku. 2014. PMID: 25675814 Review. Japanese. No abstract available.

• Alloantigen specific T regulatory cells in transplant tolerance.

  Hall BM, Tran G, Hodgkinson SJ. Hall BM, et al. Int Immunopharmacol. 2009 May;9(5):570-4. doi: 10.1016/j.intimp.2009.01.016. Epub 2009 Jan 29. Int Immunopharmacol. 2009. PMID: 19539571 Review.

Cited by

• Dysregulation of T cell subsets in the pathogenesis of hypertension.

  Chen S, Agrawal DK. Chen S, et al. Curr Hypertens Rep. 2015 Feb;17(2):8. doi: 10.1007/s11906-014-0521-1. Curr Hypertens Rep. 2015. PMID: 25633669 Free PMC article. Review.

• Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.

  Rajasekaran N, Wang N, Truong P, Rinderknecht C, Macaubas C, Beilhack GF, Shizuru JA, Mellins ED. Rajasekaran N, et al. Arthritis Rheum. 2013 Mar;65(3):681-92. doi: 10.1002/art.37800. Arthritis Rheum. 2013. PMID: 23233229 Free PMC article.

• Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor.

  Tokano M, Matsushita S, Takagi R, Yamamoto T, Kawano M. Tokano M, et al. Brain Behav Immun Health. 2022 Oct 28;26:100544. doi: 10.1016/j.bbih.2022.100544. eCollection 2022 Dec. Brain Behav Immun Health. 2022. PMID: 36467126 Free PMC article.

• Relevance of Regulatory T Cells during Colorectal Cancer Development.

  Olguín JE, Medina-Andrade I, Rodríguez T, Rodríguez-Sosa M, Terrazas LI. Olguín JE, et al. Cancers (Basel). 2020 Jul 14;12(7):1888. doi: 10.3390/cancers12071888. Cancers (Basel). 2020. PMID: 32674255 Free PMC article. Review.

• Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine.

  Nurkhametova D, Kudryavtsev I, Khayrutdinova O, Serebryakova M, Altunbaev R, Malm T, Giniatullin R. Nurkhametova D, et al. Front Cell Neurosci. 2018 Sep 25;12:326. doi: 10.3389/fncel.2018.00326. eCollection 2018. Front Cell Neurosci. 2018. PMID: 30319363 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • SciCrunch