Biologically active ibogan and vallesamine derivatives from Tabernaemontana divaricata - PubMed

Biologically active ibogan and vallesamine derivatives from Tabernaemontana divaricata

Toh-Seok Kam et al. Chem Biodivers. 2004 Apr.

Abstract

Six new indole alkaloids, viz., (3S)-3-cyanocoronaridine (2), (3S)-3-cyanoisovoacangine (3), conolobine A (5), conolobine B (6), conolidine (7), and (3R/3S)-3-ethoxyvoacangine (8), in addition to 36 known ones, were obtained from the stem-bark extract of the Malayan Tabernaemontana divaricata. The structures were determined by NMR and MS analysis. The CN-substituted alkaloids showed appreciable cytotoxicity towards the KB human oral epidermoid carcinoma cell-line.

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