Proteasome-independent functions of ubiquitin in endocytosis and signaling - PubMed

Affiliations

• PMID: 17218518
• DOI: 10.1126/science.1127085

Review

Proteasome-independent functions of ubiquitin in endocytosis and signaling

Debdyuti Mukhopadhyay et al. Science. 2007.

Abstract

Ubiquitination is a reversible posttranslational modification of cellular proteins, in which a 76-amino acid polypeptide, ubiquitin, is primarily attached to the epsilon-amino group of lysines in target proteins. Ubiquitination is a major player in regulating a broad host of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control. Aberrations in the ubiquitination system are implicated in pathogenesis of some diseases, certain malignancies, neurodegenerative disorders, and pathologies of the inflammatory immune response. Here, we discuss the proteasome-independent roles of ubiquitination in signaling and endocytosis.

Similar articles

• The ubiquitin system: from basic mechanisms to the patient bed.

  Ciechanover A, Iwai K. Ciechanover A, et al. IUBMB Life. 2004 Apr;56(4):193-201. doi: 10.1080/1521654042000223616. IUBMB Life. 2004. PMID: 15230346 Review.

• Non-26S proteasome proteolytic role of ubiquitin in plant endocytosis and endosomal trafficking(F).

  Tian M, Xie Q. Tian M, et al. J Integr Plant Biol. 2013 Jan;55(1):54-63. doi: 10.1111/jipb.12007. J Integr Plant Biol. 2013. PMID: 23137267 Review.

• Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.

  Ciechanover A. Ciechanover A. Exp Biol Med (Maywood). 2006 Jul;231(7):1197-211. doi: 10.1177/153537020623100705. Exp Biol Med (Maywood). 2006. PMID: 16816126 Review.

• Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches.

  Paul S. Paul S. Bioessays. 2008 Nov;30(11-12):1172-84. doi: 10.1002/bies.20852. Bioessays. 2008. PMID: 18937370 Review.

Cited by

• The KEEP ON GOING protein of Arabidopsis regulates intracellular protein trafficking and is degraded during fungal infection.

  Gu Y, Innes RW. Gu Y, et al. Plant Cell. 2012 Nov;24(11):4717-30. doi: 10.1105/tpc.112.105254. Epub 2012 Nov 27. Plant Cell. 2012. PMID: 23192225 Free PMC article.

• Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system.

  Moran-Crusio K, Reavie LB, Aifantis I. Moran-Crusio K, et al. Trends Immunol. 2012 Jul;33(7):357-63. doi: 10.1016/j.it.2012.01.009. Epub 2012 Feb 18. Trends Immunol. 2012. PMID: 22349458 Free PMC article. Review.

• Mutant ubiquitin attenuates interleukin-1β- and tumor necrosis factor-α-induced pro-inflammatory signaling in human astrocytic cells.

  Choi K, Park J, Lee J, Han EC, Choi C. Choi K, et al. PLoS One. 2013 Jul 3;8(7):e67891. doi: 10.1371/journal.pone.0067891. Print 2013. PLoS One. 2013. PMID: 23844119 Free PMC article.

• Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.

  Rao T, Gao R, Takada S, Al Abo M, Chen X, Walters KJ, Pommier Y, Aihara H. Rao T, et al. Nucleic Acids Res. 2016 Dec 1;44(21):10201-10215. doi: 10.1093/nar/gkw719. Epub 2016 Aug 19. Nucleic Acids Res. 2016. PMID: 27543075 Free PMC article.

• Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo.

  Richman SA, Wang LC, Moon EK, Khire UR, Albelda SM, Milone MC. Richman SA, et al. Mol Ther. 2020 Jul 8;28(7):1600-1613. doi: 10.1016/j.ymthe.2020.06.004. Epub 2020 Jun 11. Mol Ther. 2020. PMID: 32559430 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc