New developments in FcepsilonRI regulation, function and inhibition - PubMed

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• PMID: 17438574
• DOI: 10.1038/nri2072

Review

New developments in FcepsilonRI regulation, function and inhibition

Stefan Kraft et al. Nat Rev Immunol. 2007 May.

Abstract

The high-affinity Fc receptor for IgE (FcepsilonRI), a multimeric immune receptor, is a crucial structure for IgE-mediated allergic reactions. In recent years, advances have been made in several important areas of the study of FcepsilonRI. The first area relates to FcepsilonRI-mediated biological responses that are antigen independent. The second area encompasses the biological relevance of the distinct signalling pathways that are activated by FcepsilonRI; and the third area relates to the accumulated evidence for the tight control of FcepsilonRI signalling through a broad array of inhibitory mechanisms, which are being developed into promising therapeutic approaches.

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