Antiretroviral therapy and premature delivery in diagnosed HIV-infected women in the United Kingdom and Ireland - PubMed
- ️Mon Jan 01 2007
Multicenter Study
. 2007 May 11;21(8):1019-26.
doi: 10.1097/QAD.0b013e328133884b.
Affiliations
- PMID: 17457096
- DOI: 10.1097/QAD.0b013e328133884b
Multicenter Study
Antiretroviral therapy and premature delivery in diagnosed HIV-infected women in the United Kingdom and Ireland
Claire L Townsend et al. AIDS. 2007.
Abstract
Objective: To explore the association between antiretroviral therapy in pregnancy and premature delivery, birthweight, stillbirth and neonatal mortality, in pregnancies in HIV-infected women delivering between 1990 and 2005.
Design: Pregnancies in women with diagnosed HIV infection in the UK and Ireland are notified to the National Study of HIV in Pregnancy and Childhood (NSHPC) through a well-established surveillance scheme.
Results: The prematurity rate (< 37 weeks gestation) was higher in women on highly active antiretroviral therapy (HAART) (14.1%, 476/3384) than in women on mono/dual therapy (10.1%, 107/1061), even after adjusting for ethnicity, maternal age, clinical status and injecting drug use as the source of HIV acquisition [adjusted odds ratio (AOR) = 1.51, 95% confidence interval (CI), 1.19-1.93; P = 0.001]. Delivery at < 35 weeks was even more strongly associated with HAART (AOR = 2.34; 95% CI, 1.64-3.37; P < 0.001). The effect was the same whether or not HAART included a protease inhibitor. In comparison with exposure to mono/dual therapy, exposure to HAART was associated with lower birthweight standardized for gestational age (P < 0.001), and an increased risk of stillbirth (AOR = 2.27; 95% CI, 0.96-5.41; P = 0.063).
Conclusions: These findings, based on comprehensive population surveillance, demonstrate an increased risk of prematurity associated with HAART, and a possible association with other perinatal outcomes, including stillbirth and birthweight. Although the beneficial effects of antiretroviral therapy on mother-to-child transmission are indisputable, monitoring antiretroviral therapy in pregnancy remains a priority.
Comment in
-
Considerations on the increase in blood pressure among antiretroviral-naive patients starting HAART.
Martínez E, López Bernaldo de Quirós JC, Miralles C, Podzamczer D. Martínez E, et al. AIDS. 2007 Jan 30;21(3):384-6. doi: 10.1097/QAD.0b013e328011daef. AIDS. 2007. PMID: 17255753 No abstract available.
Similar articles
-
Townsend CL, Cortina-Borja M, Peckham CS, de Ruiter A, Lyall H, Tookey PA. Townsend CL, et al. AIDS. 2008 May 11;22(8):973-81. doi: 10.1097/QAD.0b013e3282f9b67a. AIDS. 2008. PMID: 18453857
-
Effect of antiretroviral therapy on pregnancy outcome in HIV-1 positive women.
Kowalska A, Niemiec T, El Midaoui A, Burkacka E. Kowalska A, et al. Med Wieku Rozwoj. 2003 Oct-Dec;7(4 Pt 1):459-68. Med Wieku Rozwoj. 2003. PMID: 15010556 Clinical Trial.
-
Grosch-Woerner I, Puch K, Maier RF, Niehues T, Notheis G, Patel D, Casteleyn S, Feiterna-Sperling C, Groeger S, Zaknun D; Multicenter Interdisciplinary Study Group Germany/Austria. Grosch-Woerner I, et al. HIV Med. 2008 Jan;9(1):6-13. doi: 10.1111/j.1468-1293.2008.00520.x. HIV Med. 2008. PMID: 18199167 Clinical Trial.
-
Thorne C, Newell ML. Thorne C, et al. Drug Saf. 2007;30(3):203-13. doi: 10.2165/00002018-200730030-00004. Drug Saf. 2007. PMID: 17343429 Review.
-
Brocklehurst P, French R. Brocklehurst P, et al. Br J Obstet Gynaecol. 1998 Aug;105(8):836-48. doi: 10.1111/j.1471-0528.1998.tb10227.x. Br J Obstet Gynaecol. 1998. PMID: 9746375 Review.
Cited by
-
Mesfin YM, Kibret KT, Taye A. Mesfin YM, et al. Reprod Health. 2016 Apr 5;13:30. doi: 10.1186/s12978-016-0149-5. Reprod Health. 2016. PMID: 27048501 Free PMC article. Review.
-
Shapiro RL, Souda S, Parekh N, Binda K, Kayembe M, Lockman S, Svab P, Babitseng O, Powis K, Jimbo W, Creek T, Makhema J, Essex M, Roberts DJ. Shapiro RL, et al. PLoS One. 2012;7(2):e31580. doi: 10.1371/journal.pone.0031580. Epub 2012 Feb 22. PLoS One. 2012. PMID: 22384039 Free PMC article.
-
Djeha A, Girard S, Trottier H, Kakkar F, Soudeyns H, Boucher M, Lapointe N, Boucoiran I. Djeha A, et al. BMC Pregnancy Childbirth. 2019 Dec 9;19(1):482. doi: 10.1186/s12884-019-2600-4. BMC Pregnancy Childbirth. 2019. PMID: 31815612 Free PMC article.
-
Mid-trimester cervical length not associated with HIV status among pregnant women in Botswana.
Liff I, Zash R, Mingochi D, Gaonakala FT, Diseko M, Mayondi G, Johnson K, James K, Makhema J, Shapiro R, Wylie BJ. Liff I, et al. PLoS One. 2020 Mar 11;15(3):e0229500. doi: 10.1371/journal.pone.0229500. eCollection 2020. PLoS One. 2020. PMID: 32160214 Free PMC article.
-
Chetty T, Thorne C, Coutsoudis A. Chetty T, et al. PLoS One. 2018 Feb 22;13(2):e0192805. doi: 10.1371/journal.pone.0192805. eCollection 2018. PLoS One. 2018. PMID: 29470508 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical