Steady-state lopinavir levels in third trimester of pregnancy - PubMed

Comment

Steady-state lopinavir levels in third trimester of pregnancy

Fiona Lyons et al. AIDS. 2007.

Abstract

Stek and colleagues reported low lopinavir levels in the third trimester of pregnancy at standard dosing. Since their initial report in 2003, we have taken steady-state trough lopinavir levels in all pregnant women in the third trimester; the results of 26 women on a lopinavir/ritonavir regimen are reported. The median trough level was 3.66 microg/ml, range 0.25-9.97; the median HIV viral load was 49 copies/ml at delivery. All infants were HIV polymerase chain reaction negative at 3 months.

Comment on

• Reduced lopinavir exposure during pregnancy.

  Stek AM, Mirochnick M, Capparelli E, Best BM, Hu C, Burchett SK, Elgie C, Holland DT, Smith E, Tuomala R, Cotter A, Read JS. Stek AM, et al. AIDS. 2006 Oct 3;20(15):1931-9. doi: 10.1097/01.aids.0000247114.43714.90. AIDS. 2006. PMID: 16988514 Clinical Trial.

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