Sex determination: controlling the master - PubMed

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• PMID: 17470347
• DOI: 10.1016/j.cub.2007.03.012

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Sex determination: controlling the master

Douglas A Harrison. Curr Biol. 2007.

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Abstract

Sex is determined in Drosophila by the activity of the Sex-lethal master regulator. Activity of Sex-lethal is initiated early in females by chromosome-counting transcription factors, then reinforced by signaling through the Janus kinase pathway.

Comment on

• Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl.

  Avila FW, Erickson JW. Avila FW, et al. Curr Biol. 2007 Apr 3;17(7):643-8. doi: 10.1016/j.cub.2007.02.038. Epub 2007 Mar 15. Curr Biol. 2007. PMID: 17363251

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