Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study - PubMed

Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study

Andrew H Kemp et al. Psychiatry Res. 2007.

Abstract

Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.

Similar articles

• A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.

  Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL. Shin LM, et al. Arch Gen Psychiatry. 2005 Mar;62(3):273-81. doi: 10.1001/archpsyc.62.3.273. Arch Gen Psychiatry. 2005. PMID: 15753240

• Neural correlates of trauma script-imagery in posttraumatic stress disorder with and without comorbid major depression: a functional MRI investigation.

  Lanius RA, Frewen PA, Girotti M, Neufeld RW, Stevens TK, Densmore M. Lanius RA, et al. Psychiatry Res. 2007 May 15;155(1):45-56. doi: 10.1016/j.pscychresns.2006.11.006. Epub 2007 Apr 6. Psychiatry Res. 2007. PMID: 17412567

• Dissociative responses to conscious and non-conscious fear impact underlying brain function in post-traumatic stress disorder.

  Felmingham K, Kemp AH, Williams L, Falconer E, Olivieri G, Peduto A, Bryant R. Felmingham K, et al. Psychol Med. 2008 Dec;38(12):1771-80. doi: 10.1017/S0033291708002742. Epub 2008 Feb 25. Psychol Med. 2008. PMID: 18294420

• Amygdala, medial prefrontal cortex, and hippocampal function in PTSD.

  Shin LM, Rauch SL, Pitman RK. Shin LM, et al. Ann N Y Acad Sci. 2006 Jul;1071:67-79. doi: 10.1196/annals.1364.007. Ann N Y Acad Sci. 2006. PMID: 16891563 Review.

• Is posttraumatic stress disorder a stress-induced fear circuitry disorder?

  Shin LM, Handwerger K. Shin LM, et al. J Trauma Stress. 2009 Oct;22(5):409-15. doi: 10.1002/jts.20442. Epub 2009 Sep 9. J Trauma Stress. 2009. PMID: 19743481 Review.

Cited by

• Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders.

  Bremner JD, Gurel NZ, Wittbrodt MT, Shandhi MH, Rapaport MH, Nye JA, Pearce BD, Vaccarino V, Shah AJ, Park J, Bikson M, Inan OT. Bremner JD, et al. J Pers Med. 2020 Sep 9;10(3):119. doi: 10.3390/jpm10030119. J Pers Med. 2020. PMID: 32916852 Free PMC article. Review.

• Beyond postpartum depression: posttraumatic stress-depressive response following childbirth.

  Dekel S, Ein-Dor T, Dishy GA, Mayopoulos PA. Dekel S, et al. Arch Womens Ment Health. 2020 Aug;23(4):557-564. doi: 10.1007/s00737-019-01006-x. Epub 2019 Oct 25. Arch Womens Ment Health. 2020. PMID: 31650283 Free PMC article.

• Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.

  Bremner JD, Gazi AH, Lambert TP, Nawar A, Harrison AB, Welsh JW, Vaccarino V, Walton KM, Jaquemet N, Mermin-Bunnell K, Mesfin H, Gray TA, Ross K, Saks G, Tomic N, Affadzi D, Bikson M, Shah AJ, Dunn KE, Giordano NA, Inan OT. Bremner JD, et al. Ann Depress Anxiety. 2023;10(1):1117. Epub 2023 Aug 2. Ann Depress Anxiety. 2023. PMID: 38074313 Free PMC article.

• Exploring the gold-standard: Evidence for a two-factor model of the Clinician Administered PTSD Scale for the DSM-5.

  Hunt JC, Chesney SA, Jorgensen TD, Schumann NR, deRoon-Cassini TA. Hunt JC, et al. Psychol Trauma. 2018 Sep;10(5):551-558. doi: 10.1037/tra0000310. Epub 2017 Aug 10. Psychol Trauma. 2018. PMID: 28795824 Free PMC article.

• Neural functional and structural correlates of childhood maltreatment in women with intimate-partner violence-related posttraumatic stress disorder.

  Fonzo GA, Flagan TM, Sullivan S, Allard CB, Grimes EM, Simmons AN, Paulus MP, Stein MB. Fonzo GA, et al. Psychiatry Res. 2013 Feb 28;211(2):93-103. doi: 10.1016/j.pscychresns.2012.08.006. Epub 2012 Nov 13. Psychiatry Res. 2013. PMID: 23154098 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Medical

  • MedlinePlus Health Information