Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity - PubMed

Affiliations

• PMID: 17668232
• DOI: 10.1007/s00421-007-0522-8

Randomized Controlled Trial

Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity

J J Thomsen et al. Eur J Appl Physiol. 2007 Nov.

Abstract

The effects of recombinant human erythropoietin (rHuEpo) treatment on aerobic power (VO2max) are well documented, but little is known about the effects of rHuEpo on submaximal exercise performance. The present study investigated the effect on performance (ergometer cycling, 20-30 min at 80% of maximal attainable workload), and for this purpose eight subjects received either 5,000 IU rHuEpo or placebo every second day for 14 days, and subsequently a single dose of 5,000 IU/placebo weekly/10 weeks. Exercise performance was evaluated before treatment and after 4 and 11 weeks of treatment. With rHuEpo treatment VO2max increased (P<0.05) by 12.6 and 11.6% in week 4 and 11, respectively, and time-to-exhaustion (80% VO2max) was increased by 54.0 and 54.3% (P<0.05) after 4 and 11 weeks of treatment, respectively. However, when normalizing the workload to the same relative intensity (only done at time point week 11), TTE was decreased by 26.8% as compared to pre rHuEpo administration. In conclusion, in healthy non-athlete subjects rHuEpo administration prolongs submaximal exercise performance by about 54% independently of the approximately 12% increase in VO2max.

Comment in

• Mechanism by which rHuEPO improves submaximal exercise performance.

  Noakes TD. Noakes TD. Eur J Appl Physiol. 2008 Jul;103(4):485. doi: 10.1007/s00421-008-0712-z. Eur J Appl Physiol. 2008. PMID: 18368420 No abstract available.

Similar articles

• Effects of erythropoietin on cycling performance of well trained cyclists: a double-blind, randomised, placebo-controlled trial.

  Heuberger JAAC, Rotmans JI, Gal P, Stuurman FE, van 't Westende J, Post TE, Daniels JMA, Moerland M, van Veldhoven PLJ, de Kam ML, Ram H, de Hon O, Posthuma JJ, Burggraaf J, Cohen AF. Heuberger JAAC, et al. Lancet Haematol. 2017 Aug;4(8):e374-e386. doi: 10.1016/S2352-3026(17)30105-9. Epub 2017 Jun 29. Lancet Haematol. 2017. PMID: 28669689 Clinical Trial.

• Injections of recombinant human erythropoietin increases lactate influx into erythrocytes.

  Connes P, Caillaud C, Mercier J, Bouix D, Casties JF. Connes P, et al. J Appl Physiol (1985). 2004 Jul;97(1):326-32. doi: 10.1152/japplphysiol.00715.2003. Epub 2004 Feb 13. J Appl Physiol (1985). 2004. PMID: 14966016 Clinical Trial.

• Low dose exogenous erythropoietin elicits an ergogenic effect in standardbred horses.

  McKeever KH, Agans JM, Geiser S, Lorimer PJ, Maylin GA. McKeever KH, et al. Equine Vet J Suppl. 2006 Aug;(36):233-8. doi: 10.1111/j.2042-3306.2006.tb05545.x. Equine Vet J Suppl. 2006. PMID: 17402424 Clinical Trial.

• Effects of erythropoietin abuse on exercise performance.

  Sgrò P, Sansone M, Sansone A, Romanelli F, Di Luigi L. Sgrò P, et al. Phys Sportsmed. 2018 Feb;46(1):105-115. doi: 10.1080/00913847.2018.1402663. Epub 2017 Nov 13. Phys Sportsmed. 2018. PMID: 29113535 Review.

• Optimizing strength training for running and cycling endurance performance: A review.

  Rønnestad BR, Mujika I. Rønnestad BR, et al. Scand J Med Sci Sports. 2014 Aug;24(4):603-12. doi: 10.1111/sms.12104. Epub 2013 Aug 5. Scand J Med Sci Sports. 2014. PMID: 23914932 Review.

Cited by

• Haemoglobin concentration and mass as determinants of exercise performance and of surgical outcome.

  Otto JM, Montgomery HE, Richards T. Otto JM, et al. Extrem Physiol Med. 2013 Nov 26;2(1):33. doi: 10.1186/2046-7648-2-33. Extrem Physiol Med. 2013. PMID: 24280034 Free PMC article.

• Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study.

  Mille-Hamard L, Billat VL, Henry E, Bonnamy B, Joly F, Benech P, Barrey E. Mille-Hamard L, et al. BMC Med Genomics. 2012 Jun 29;5:29. doi: 10.1186/1755-8794-5-29. BMC Med Genomics. 2012. PMID: 22748015 Free PMC article.

• Screening for recombinant human erythropoietin using [Hb], reticulocytes, the OFF(hr score), OFF(z score) and Hb(z score): status of the Blood Passport.

  Bornø A, Aachmann-Andersen NJ, Munch-Andersen T, Hulston CJ, Lundby C. Bornø A, et al. Eur J Appl Physiol. 2010 Jun;109(3):537-43. doi: 10.1007/s00421-010-1370-5. Epub 2010 Feb 2. Eur J Appl Physiol. 2010. PMID: 20127125

• 'Blood doping' from Armstrong to prehabilitation: manipulation of blood to improve performance in athletes and physiological reserve in patients.

  Plumb JO, Otto JM, Grocott MP. Plumb JO, et al. Extrem Physiol Med. 2016 Feb 29;5:5. doi: 10.1186/s13728-016-0046-0. eCollection 2016. Extrem Physiol Med. 2016. PMID: 26929820 Free PMC article. Review.

• Time to exhaustion at maximal lactate steady state is similar for cycling and running in moderately trained subjects.

  Fontana P, Boutellier U, Knöpfli-Lenzin C. Fontana P, et al. Eur J Appl Physiol. 2009 Sep;107(2):187-92. doi: 10.1007/s00421-009-1111-9. Epub 2009 Jun 24. Eur J Appl Physiol. 2009. PMID: 19551404 Clinical Trial.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Other Literature Sources

  • The Lens - Patent Citations Database