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Functional specialization of the primate frontal cortex during decision making - PubMed

  • ️Mon Jan 01 2007

Review

Functional specialization of the primate frontal cortex during decision making

Daeyeol Lee et al. J Neurosci. 2007.

Abstract

Economic theories of decision making are based on the principle of utility maximization, and reinforcement-learning theory provides computational algorithms that can be used to estimate the overall reward expected from alternative choices. These formal models not only account for a large range of behavioral observations in human and animal decision makers, but also provide useful tools for investigating the neural basis of decision making. Nevertheless, in reality, decision makers must combine different types of information about the costs and benefits associated with each available option, such as the quality and quantity of expected reward and required work. In this article, we put forward the hypothesis that different subdivisions of the primate frontal cortex may be specialized to focus on different aspects of dynamic decision-making processes. In this hypothesis, the lateral prefrontal cortex is primarily involved in maintaining the state representation necessary to identify optimal actions in a given environment. In contrast, the orbitofrontal cortex and the anterior cingulate cortex might be primarily involved in encoding and updating the utilities associated with different sensory stimuli and alternative actions, respectively. These cortical areas are also likely to contribute to decision making in a social context.

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Figure 1.
Figure 1.

A, B, Medial (A) and lateral (B) view of the rhesus monkey's brain showing the lateral prefrontal cortex, the orbitofrontal cortex, and the anterior cingulate cortex.

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References

    1. Amemori K, Sawaguchi T. Contrasting effects of reward expectation on sensory and motor memories in primate prefrontal neurons. Cereb Cortex. 2006;16:1002–1015. - PubMed
    1. Amodio DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006;7:268–277. - PubMed
    1. Bachevalier J, Loveland KA. The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism. Neurosci Biobehav Rev. 2006;30:97–117. - PubMed
    1. Barraclough DJ, Conroy ML, Lee D. Prefrontal cortex and decision making in a mixed-strategy game. Nat Neurosci. 2004;7:404–410. - PubMed
    1. Bechara A, Damasio H, Damasio AR. Emotion, decision making and the orbitofrontal cortex. Cereb Cortex. 2000;10:295–307. - PubMed

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