Nephrin--a unique structural and signaling protein of the kidney filter - PubMed

Affiliations

• PMID: 17766183
• DOI: 10.1016/j.molmed.2007.06.006

Review

Nephrin--a unique structural and signaling protein of the kidney filter

Jaakko Patrakka et al. Trends Mol Med. 2007 Sep.

Abstract

Since the discovery of nephrin, the first integral component of the slit diaphragm to be identified, the podocyte slit pore has become a major focus in research concerning the glomerular filtration barrier. Nephrin is a central component of the glomerular ultrafilter, with both structural and signaling functions. The extracellular domain of nephrin and other components of the slit diaphragm seem to form a porous molecular sieve. The intracellular domain of nephrin is associated with linker proteins, such as CD2-associated protein and Nck proteins that can connect nephrin to the actin cytoskeleton. Alterations in nephrin interactions with other proteins during development or injury can lead to complex signaling reactions aimed at establishing or restoring the filter function.

Similar articles

• Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.

  Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE, Pawson T. Jones N, et al. Nature. 2006 Apr 6;440(7085):818-23. doi: 10.1038/nature04662. Epub 2006 Mar 8. Nature. 2006. PMID: 16525419

• Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.

  Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB. Verma R, et al. J Clin Invest. 2006 May;116(5):1346-59. doi: 10.1172/JCI27414. Epub 2006 Mar 16. J Clin Invest. 2006. PMID: 16543952 Free PMC article.

• Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes.

  Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW, Saleem MA. Coward RJ, et al. J Am Soc Nephrol. 2005 Mar;16(3):629-37. doi: 10.1681/ASN.2004030172. Epub 2005 Jan 19. J Am Soc Nephrol. 2005. PMID: 15659563

• Nephrin-signature molecule of the glomerular podocyte?

  Welsh GI, Saleem MA. Welsh GI, et al. J Pathol. 2010 Feb;220(3):328-37. doi: 10.1002/path.2661. J Pathol. 2010. PMID: 19950250 Review.

• Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney.

  Tryggvason K, Ruotsalainen V, Wartiovaara J. Tryggvason K, et al. Int J Dev Biol. 1999;43(5):445-51. Int J Dev Biol. 1999. PMID: 10535322 Review.

Cited by

• Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach.

  Yu SM, Nissaisorakarn P, Husain I, Jim B. Yu SM, et al. Front Med (Lausanne). 2018 Sep 11;5:221. doi: 10.3389/fmed.2018.00221. eCollection 2018. Front Med (Lausanne). 2018. PMID: 30255020 Free PMC article. Review.

• c-mip impairs podocyte proximal signaling and induces heavy proteinuria.

  Zhang SY, Kamal M, Dahan K, Pawlak A, Ory V, Desvaux D, Audard V, Candelier M, BenMohamed F, Matignon M, Christov C, Decrouy X, Bernard V, Mangiapan G, Lang P, Guellaën G, Ronco P, Sahali D. Zhang SY, et al. Sci Signal. 2010 May 18;3(122):ra39. doi: 10.1126/scisignal.2000678. Sci Signal. 2010. PMID: 20484117 Free PMC article.

• Molecular and Cellular Mechanisms for Proteinuria in Minimal Change Disease.

  Bertelli R, Bonanni A, Caridi G, Canepa A, Ghiggeri GM. Bertelli R, et al. Front Med (Lausanne). 2018 Jun 11;5:170. doi: 10.3389/fmed.2018.00170. eCollection 2018. Front Med (Lausanne). 2018. PMID: 29942802 Free PMC article. Review.

• Signaling in regulation of podocyte phenotypes.

  Chuang PY, He JC. Chuang PY, et al. Nephron Physiol. 2009;111(2):p9-15. doi: 10.1159/000191075. Epub 2009 Jan 13. Nephron Physiol. 2009. PMID: 19142027 Free PMC article. Review.

• Neph1 is reduced in primary focal segmental glomerulosclerosis, minimal change nephrotic syndrome, and corresponding experimental animal models of adriamycin-induced nephropathy and puromycin aminonucleoside nephrosis.

  Hulkko J, Patrakka J, Lal M, Tryggvason K, Hultenby K, Wernerson A. Hulkko J, et al. Nephron Extra. 2014 Sep 19;4(3):146-54. doi: 10.1159/000365091. eCollection 2014 Sep. Nephron Extra. 2014. PMID: 25404935 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database