Autoimmune reactions after electro-oxidation of IgG from healthy persons: relevance of electric current and antioxidants - PubMed

Autoimmune reactions after electro-oxidation of IgG from healthy persons: relevance of electric current and antioxidants

Borut Bozic et al. Ann N Y Acad Sci. 2007 Aug.

Abstract

Proteins, including immunoglobulins, can be modified by oxidation. Extensive oxidation of immunoglobulins leads to denaturation and loss of biological activity, while initial steps of oxidation may change their specificity due to chemical alteration of the paratope. Electro-oxidation of the IgG fraction from healthy persons progress to auto-immunoreactivity, as shown for several autoantibodies including anti-beta2-glycoprotein I. Changes in immunoreactivity of IgG due to oxidative reactions highly depend on electric current and levels of serum antioxidants. Autoimmune reactions, leading to certain autoimmune diseases, may be partially a consequence of unbalanced antioxidative status of an individual.

Similar articles

• Changes in avidity and specificity of IgG during electro-oxidation. Relevance of binding of antibodies to beta2-GPI.

  Bozic B, Cucnik S, Kveder T, Rozman B. Bozic B, et al. Autoimmun Rev. 2006 Nov;6(1):28-32. doi: 10.1016/j.autrev.2005.12.005. Epub 2006 Jan 27. Autoimmun Rev. 2006. PMID: 17110313 Review.

• Autoimmune and proinflammatory activity of oxidized immunoglobulins.

  Omersel J, Jurgec I, Cucnik S, Kveder T, Rozman B, Sodin-Semrl S, Bozic B. Omersel J, et al. Autoimmun Rev. 2008 Jul;7(7):523-9. doi: 10.1016/j.autrev.2008.04.005. Epub 2008 Apr 30. Autoimmun Rev. 2008. PMID: 18625440

• Autoantibodies unmasked by redox reactions.

  McIntyre JA, Wagenknecht DR, Faulk WP. McIntyre JA, et al. J Autoimmun. 2005 Jun;24(4):311-7. doi: 10.1016/j.jaut.2005.03.005. J Autoimmun. 2005. PMID: 15927793

• Sugar-free antibodies--the bacterial solution to autoimmunity?

  Allhorn M, Collin M. Allhorn M, et al. Ann N Y Acad Sci. 2009 Sep;1173:664-9. doi: 10.1111/j.1749-6632.2009.04739.x. Ann N Y Acad Sci. 2009. PMID: 19758213 Review.

• Low-affinity Fcgamma receptors, autoimmunity and infection.

  Willcocks LC, Smith KG, Clatworthy MR. Willcocks LC, et al. Expert Rev Mol Med. 2009 Aug 13;11:e24. doi: 10.1017/S1462399409001161. Expert Rev Mol Med. 2009. PMID: 19674504 Review.

Cited by

• Autoimmune reactivity of IgM acquired after oxidation.

  Omersel J, Avberšek-Lužnik I, Grabnar PA, Kveder T, Rozman B, Božič B. Omersel J, et al. Redox Rep. 2011;16(6):248-56. doi: 10.1179/174329211X13190184351680. Redox Rep. 2011. PMID: 22195993 Free PMC article.

• Electrohypersensitivity as a Newly Identified and Characterized Neurologic Pathological Disorder: How to Diagnose, Treat, and Prevent It.

  Belpomme D, Irigaray P. Belpomme D, et al. Int J Mol Sci. 2020 Mar 11;21(6):1915. doi: 10.3390/ijms21061915. Int J Mol Sci. 2020. PMID: 32168876 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Medical

  • MedlinePlus Health Information