Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts - PubMed

Affiliations

• PMID: 18163387
• DOI: 10.1002/ajmg.b.30642

Comparative Study

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts

Concepcion Vaquero-Lorenzo et al. Am J Med Genet B Neuropsychiatr Genet. 2008.

Abstract

Serotonin (5-HT) receptors may have a role in suicidal behavior. Previous studies have shown an association between the T102C polymorphism of the 5-HT2a receptor gene and suicidal behavior. However, negative findings have also been reported. We examined the association between the T102C and C1354T (His452Tyr) polymorphisms of the 5-HT2a receptor gene and suicide attempts. Four hundred forty-one suicide attempters, 339 psychiatric patients, and 410 healthy controls were compared for genotypes of the T102C and C1354T (His452Tyr) polymorphisms. There were significant differences in the distribution of the three genotypes (TT, TC, and CC) of the T102C polymorphism in the three groups (controls, psychiatric patients, and suicide attempters). There was an excess of C/C genotypes in the suicide attempter group compared with the control group, but there were no significant differences between suicide attempters and psychiatric controls. We found no association between the C1354T polymorphism and suicide attempts. The C allele of the T102C polymorphism of the 5-HT2A receptor gene may be associated with biological susceptibility for suicidal behavior or psychiatric conditions.

Similar articles

• Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts.

  Saiz PA, García-Portilla MP, Paredes B, Arango C, Morales B, Alvarez V, Coto E, Bascaran MT, Bousoño M, Bobes J. Saiz PA, et al. Psychiatr Genet. 2008 Oct;18(5):213-8. doi: 10.1097/YPG.0b013e3283050ada. Psychiatr Genet. 2008. PMID: 18797395

• Family-based association study of 5-HT(2A) receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents.

  Zalsman G, Frisch A, Baruch-Movshovits R, Sher L, Michaelovsky E, King RA, Fischel T, Hermesh H, Goldberg P, Gorlyn M, Misgav S, Apter A, Tyano S, Weizman A. Zalsman G, et al. Int J Adolesc Med Health. 2005 Jul-Sep;17(3):231-8. doi: 10.1515/ijamh.2005.17.3.231. Int J Adolesc Med Health. 2005. PMID: 16231475

• Association between serotonin 2A receptor genetic variations, stressful life events and suicide.

  Ghasemi A, Seifi M, Baybordi F, Danaei N, Samadi Rad B. Ghasemi A, et al. Gene. 2018 Jun 5;658:191-197. doi: 10.1016/j.gene.2018.03.023. Epub 2018 Mar 9. Gene. 2018. PMID: 29526601

• Association study of T102C 5-HT(2A) polymorphism in schizophrenic patients: diagnosis, psychopathology, and suicidal behavior.

  Correa H, De Marco L, Boson W, Nicolato R, Teixeira AL, Campo VR, Romano-Silva MA. Correa H, et al. Dialogues Clin Neurosci. 2007;9(1):97-101. doi: 10.31887/DCNS.2007.9.1/hcorrea. Dialogues Clin Neurosci. 2007. PMID: 17506229 Free PMC article. Review.

• Genetics of the serotonergic system in suicidal behavior.

  Arango V, Huang YY, Underwood MD, Mann JJ. Arango V, et al. J Psychiatr Res. 2003 Sep-Oct;37(5):375-86. doi: 10.1016/s0022-3956(03)00048-7. J Psychiatr Res. 2003. PMID: 12849930 Review.

Cited by

• Precision medicine for suicidality: from universality to subtypes and personalization.

  Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR. Niculescu AB, et al. Mol Psychiatry. 2017 Sep;22(9):1250-1273. doi: 10.1038/mp.2017.128. Epub 2017 Aug 15. Mol Psychiatry. 2017. PMID: 28809398 Free PMC article.

• The role of the serotonergic system at the interface of aggression and suicide.

  Bortolato M, Pivac N, Muck Seler D, Nikolac Perkovic M, Pessia M, Di Giovanni G. Bortolato M, et al. Neuroscience. 2013 Apr 16;236:160-85. doi: 10.1016/j.neuroscience.2013.01.015. Epub 2013 Jan 16. Neuroscience. 2013. PMID: 23333677 Free PMC article. Review.

• Suicide: Genetics and Heritability.

  Vaquero-Lorenzo C, Vasquez MA. Vaquero-Lorenzo C, et al. Curr Top Behav Neurosci. 2020;46:63-78. doi: 10.1007/7854_2020_161. Curr Top Behav Neurosci. 2020. PMID: 32794081

• Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence.

  Wojnar M, Brower KJ, Strobbe S, Ilgen M, Matsumoto H, Nowosad I, Sliwerska E, Burmeister M. Wojnar M, et al. Alcohol Clin Exp Res. 2009 Apr;33(4):693-702. doi: 10.1111/j.1530-0277.2008.00886.x. Epub 2009 Jan 27. Alcohol Clin Exp Res. 2009. PMID: 19170664 Free PMC article.

• Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior.

  Sublette ME, Vaquero C, Baca-Garcia E, Pachano G, Huang YY, Oquendo MA, Mann JJ. Sublette ME, et al. Psychiatr Genet. 2016 Apr;26(2):81-6. doi: 10.1097/YPG.0000000000000111. Psychiatr Genet. 2016. PMID: 26513616 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley