pubmed.ncbi.nlm.nih.gov

Field defects in progression to gastrointestinal tract cancers - PubMed

️Tue Jan 01 2008

Review

Field defects in progression to gastrointestinal tract cancers

Carol Bernstein et al. Cancer Lett. 2008.

Abstract

A field of defective tissue may represent a pre-malignant stage in progression to many cancers. However, field defects are often overlooked in studies of cancer progression through assuming tissue at some distance from the cancer is normal. We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum. Common features of these field defects are reduced apoptosis competence, aberrant proliferation and genomic instability. These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression.

PubMed Disclaimer

Figures

**Fig. 1**
Colonic epithelial patches of field defects arising and expanding within pre-existing areas with field defects, in progression to adenocarcinoma. The dark area represents an adenocarcinoma.

**Fig. 2**
Probable general pathway for how a field defect may develop.

**Fig. 3**
The diagram on the left shows the location of the hepatic ducts, the common bile duct, the stomach, duodenum, pancreas and how the bile duct and pancreatic duct form the duodenal papilla where the bile and pancreatic enzymes enter the duodenum. The diagram on the right shows an enlarged area containing the duodenal papilla, with the duct mucosa indicated and red irregular forms indicating where some tumors may form.

Cited by

Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis.
Payne CM, Holubec H, Crowley-Skillicorn C, Nguyen H, Bernstein H, Wilcox G, Bernstein C. Payne CM, et al. Clin Exp Gastroenterol. 2011;4:239-53. doi: 10.2147/CEG.S24093. Epub 2011 Oct 3. Clin Exp Gastroenterol. 2011. PMID: 22162927 Free PMC article.
Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer.
Facista A, Nguyen H, Lewis C, Prasad AR, Ramsey L, Zaitlin B, Nfonsam V, Krouse RS, Bernstein H, Payne CM, Stern S, Oatman N, Banerjee B, Bernstein C. Facista A, et al. Genome Integr. 2012 Apr 11;3(1):3. doi: 10.1186/2041-9414-3-3. Genome Integr. 2012. PMID: 22494821 Free PMC article.
The ASAMET trial: a randomized, phase II, double-blind, placebo-controlled, multicenter, 2 × 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer patients.
Petrera M, Paleari L, Clavarezza M, Puntoni M, Caviglia S, Briata IM, Oppezzi M, Mislej EM, Stabuc B, Gnant M, Bachleitner-Hofmann T, Roth W, Scherer D, Haefeli WE, Ulrich CM, DeCensi A. Petrera M, et al. BMC Cancer. 2018 Dec 4;18(1):1210. doi: 10.1186/s12885-018-5126-7. BMC Cancer. 2018. PMID: 30514262 Free PMC article. Clinical Trial.
Pathologies of Precursor Lesions of Biliary Tract Carcinoma.
Nakanuma Y, Kakuda Y, Sugino T, Sato Y, Fukumura Y. Nakanuma Y, et al. Cancers (Basel). 2022 Oct 30;14(21):5358. doi: 10.3390/cancers14215358. Cancers (Basel). 2022. PMID: 36358777 Free PMC article. Review.
Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer.
Lai LA, Risques RA, Bronner MP, Rabinovitch PS, Crispin D, Chen R, Brentnall TA. Lai LA, et al. Cancer Lett. 2012 Jul 28;320(2):180-8. doi: 10.1016/j.canlet.2012.02.031. Epub 2012 Mar 2. Cancer Lett. 2012. PMID: 22387989 Free PMC article.

References

1. Bernstein C, Bernstein H, Payne CM, Garewal H. Field Defects in Progression to Adenocarcinoma of the colon and esophagus. Electronic Journal of Biotechnology. 2000. online at http://www.ejb.org/content/vol3/issue3/full/1.
1. Baylin SB, Ohm JE. Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction. Nature Reviews/Cancer. 2006;6:107–116. - PubMed
1. Bielas JH, Loeb KR, Rubin BP, True LD, Loeb LA. Human cancers express a mutator phenotype. Proc Natl Acad Sci USA. 2006;103:18238–18242. - PMC - PubMed
1. Cianfriglia F, Di Gregorio DA, Manieri A. Multiple primary tumours in patients with oral squamous cell carcinoma. Oral Oncology. 1999;35:157–163. - PubMed
1. Dhooge IJ, De Vos M, Van Cauwenberge PB. Multiple primary malignant tumors in patients with head and neck cancer: Results of a prospective study and future perspectives. Laryngoscope. 1998;108:250–256. - PubMed

Field defects in progression to gastrointestinal tract cancers - PubMed