The emerging biology of satellite cells and their therapeutic potential - PubMed

Review

The emerging biology of satellite cells and their therapeutic potential

Shihuan Kuang et al. Trends Mol Med. 2008 Feb.

Abstract

Adult skeletal muscle contains an abundant and highly accessible population of muscle stem and progenitor cells called satellite cells. The primary function of satellite cells is to mediate postnatal muscle growth and repair. Owing to their availability and remarkable capacity to regenerate damaged muscle, satellite cells and their descendent myoblasts have been considered as powerful candidates for cell-based therapies to treat muscular dystrophies and other neuromuscular diseases. However, regenerative medicine in muscle repair requires a thorough understanding of, and the ability to manipulate, the molecular mechanisms that control the proliferation, self-renewal and myogenic differentiation of satellite cells. Here, we review the latest advances in our current understanding of the quiescence, activation, proliferation and self-renewal of satellite cells and the challenges in the development of satellite cell-based regenerative medicine.

Similar articles

• Myostatin signals through Pax7 to regulate satellite cell self-renewal.

  McFarlane C, Hennebry A, Thomas M, Plummer E, Ling N, Sharma M, Kambadur R. McFarlane C, et al. Exp Cell Res. 2008 Jan 15;314(2):317-29. doi: 10.1016/j.yexcr.2007.09.012. Epub 2007 Sep 22. Exp Cell Res. 2008. PMID: 17949710

• The molecular regulation of muscle stem cell function.

  Rudnicki MA, Le Grand F, McKinnell I, Kuang S. Rudnicki MA, et al. Cold Spring Harb Symp Quant Biol. 2008;73:323-31. doi: 10.1101/sqb.2008.73.064. Epub 2009 Mar 27. Cold Spring Harb Symp Quant Biol. 2008. PMID: 19329572 Review.

• Functional analysis of homeodomain-containing transcription factor Lbx1 in satellite cells of mouse skeletal muscle.

  Watanabe S, Kondo S, Hayasaka M, Hanaoka K. Watanabe S, et al. J Cell Sci. 2007 Dec 1;120(Pt 23):4178-87. doi: 10.1242/jcs.011668. Epub 2007 Nov 14. J Cell Sci. 2007. PMID: 18003701

• Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment.

  Dhawan J, Rando TA. Dhawan J, et al. Trends Cell Biol. 2005 Dec;15(12):666-73. doi: 10.1016/j.tcb.2005.10.007. Epub 2005 Oct 21. Trends Cell Biol. 2005. PMID: 16243526 Review.

• beta-Catenin promotes self-renewal of skeletal-muscle satellite cells.

  Perez-Ruiz A, Ono Y, Gnocchi VF, Zammit PS. Perez-Ruiz A, et al. J Cell Sci. 2008 May 1;121(Pt 9):1373-82. doi: 10.1242/jcs.024885. Epub 2008 Apr 8. J Cell Sci. 2008. PMID: 18397993 Retracted.

Cited by

• New insights into the epigenetic control of satellite cells.

  Moresi V, Marroncelli N, Adamo S. Moresi V, et al. World J Stem Cells. 2015 Jul 26;7(6):945-55. doi: 10.4252/wjsc.v7.i6.945. World J Stem Cells. 2015. PMID: 26240681 Free PMC article. Review.

• High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.

  Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, Mizunoya W, Ikeuchi Y, Furuse M, Allen RE. Yamada M, et al. Am J Physiol Cell Physiol. 2010 Mar;298(3):C465-76. doi: 10.1152/ajpcell.00449.2009. Epub 2009 Dec 9. Am J Physiol Cell Physiol. 2010. PMID: 20007454 Free PMC article.

• Radiation-induced muscle fibrosis rat model: establishment and valuation.

  Zhou Y, Sheng X, Deng F, Wang H, Shen L, Zeng Y, Ni Q, Zhan S, Zhou X. Zhou Y, et al. Radiat Oncol. 2018 Aug 29;13(1):160. doi: 10.1186/s13014-018-1104-0. Radiat Oncol. 2018. PMID: 30157899 Free PMC article.

• Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.

  Martins L, Amorim WW, Gregnani MF, de Carvalho Araújo R, Qadri F, Bader M, Pesquero JB. Martins L, et al. Inflamm Res. 2023 Aug;72(8):1583-1601. doi: 10.1007/s00011-023-01766-4. Epub 2023 Jul 18. Inflamm Res. 2023. PMID: 37464053 Free PMC article.

• Proinflammatory cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) suppresses satellite cell self-renewal through inversely modulating Notch and NF-κB signaling pathways.

  Ogura Y, Mishra V, Hindi SM, Kuang S, Kumar A. Ogura Y, et al. J Biol Chem. 2013 Dec 6;288(49):35159-69. doi: 10.1074/jbc.M113.517300. Epub 2013 Oct 22. J Biol Chem. 2013. PMID: 24151074 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database