Generation of pluripotent stem cells from adult mouse liver and stomach cells - PubMed
- ️Tue Jan 01 2008
. 2008 Aug 1;321(5889):699-702.
doi: 10.1126/science.1154884. Epub 2008 Feb 14.
Affiliations
- PMID: 18276851
- DOI: 10.1126/science.1154884
Generation of pluripotent stem cells from adult mouse liver and stomach cells
Takashi Aoi et al. Science. 2008.
Erratum in
- Science.2008 Aug 1;321(5889): 641
Abstract
Induced pluripotent stem (iPS) cells have been generated from mouse and human fibroblasts by the retroviral transduction of four transcription factors. However, the cell origins and molecular mechanisms of iPS cell induction remain elusive. This report describes the generation of iPS cells from adult mouse hepatocytes and gastric epithelial cells. These iPS cell clones appear to be equivalent to embryonic stem cells in gene expression and are competent to generate germline chimeras. Genetic lineage tracings show that liver-derived iPS cells are derived from albumin-expressing cells. No common retroviral integration sites are found among multiple clones. These data suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required.
Similar articles
-
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.
Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S. Nakagawa M, et al. Nat Biotechnol. 2008 Jan;26(1):101-6. doi: 10.1038/nbt1374. Epub 2007 Nov 30. Nat Biotechnol. 2008. PMID: 18059259
-
The many ways to make an iPS cell.
Lowry WE, Plath K. Lowry WE, et al. Nat Biotechnol. 2008 Nov;26(11):1246-8. doi: 10.1038/nbt1108-1246. Nat Biotechnol. 2008. PMID: 18997764 No abstract available.
-
Effective generation of iPS cells from CD34+ cord blood cells by inhibition of p53.
Takenaka C, Nishishita N, Takada N, Jakt LM, Kawamata S. Takenaka C, et al. Exp Hematol. 2010 Feb;38(2):154-62. doi: 10.1016/j.exphem.2009.11.003. Epub 2009 Nov 14. Exp Hematol. 2010. PMID: 19922768
-
Mouse induced pluripotent stem cells.
Geoghegan E, Byrnes L. Geoghegan E, et al. Int J Dev Biol. 2008;52(8):1015-22. doi: 10.1387/ijdb.082640eg. Int J Dev Biol. 2008. PMID: 18956334 Review.
-
[Advance in study of induced pluripotent stem cells (iPS cells)].
Aoi T. Aoi T. Nihon Rinsho. 2008 May;66(5):850-6. Nihon Rinsho. 2008. PMID: 18464501 Review. Japanese.
Cited by
-
Induced pluripotent stem (iPS) cells from human fetal stem cells (hFSCs).
Spinelli V, Guillot PV, De Coppi P. Spinelli V, et al. Organogenesis. 2013 Apr-Jun;9(2):101-10. doi: 10.4161/org.25197. Epub 2013 Apr 1. Organogenesis. 2013. PMID: 23823661 Free PMC article. Review.
-
Cao S, Loh K, Pei Y, Zhang W, Han J. Cao S, et al. Protein Cell. 2012 Nov;3(11):834-45. doi: 10.1007/s13238-012-2078-6. Epub 2012 Oct 17. Protein Cell. 2012. PMID: 23073833 Free PMC article. Review.
-
Li R, Bai Y, Liu T, Wang X, Wu Q. Li R, et al. Protein Cell. 2013 Jun;4(6):415-24. doi: 10.1007/s13238-013-2089-y. Epub 2013 May 20. Protein Cell. 2013. PMID: 23686735 Free PMC article. Review.
-
Ohmine S, Squillace KA, Hartjes KA, Deeds MC, Armstrong AS, Thatava T, Sakuma T, Terzic A, Kudva Y, Ikeda Y. Ohmine S, et al. Aging (Albany NY). 2012 Jan;4(1):60-73. doi: 10.18632/aging.100428. Aging (Albany NY). 2012. PMID: 22308265 Free PMC article.
-
Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J. Nasu A, et al. PLoS One. 2013;8(1):e53771. doi: 10.1371/journal.pone.0053771. Epub 2013 Jan 31. PLoS One. 2013. PMID: 23382851 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials