Activity-based protein profiling: from enzyme chemistry to proteomic chemistry - PubMed

Review

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

Benjamin F Cravatt et al. Annu Rev Biochem. 2008.

Abstract

Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of ABPP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.

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