Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor - PubMed

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• PMID: 1837175
• DOI: 10.1126/science.1837175

Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor

J A Odin et al. Science. 1991.

Abstract

The binding of multivalent immunoglobulin G complexes to Fc receptors (Fc gamma Rs) on macrophages activates multiple immune functions. A murine macrophage cell line, but not a fibroblast cell line, that was transfected with human Fc gamma RIIA mediated phagocytosis and an intracellular Ca2+ concentration ([Ca2+]i) flux upon cross-linking of human Fc gamma RIIA. Transfected macrophages that expressed a truncated receptor lacking 17 carboxy-terminal amino acids phagocytosed small antibody complexes. However, only wild-type transfectants phagocytosed labeled erythrocytes and fluxed [Ca2+]i. Thus, the cytoplasmic domain of human Fc gamma RIIA contains distinct functional regions.

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