Lymphocyte homing and its role in the pathogenesis of IBD - PubMed

Affiliations

• PMID: 18393377
• DOI: 10.1002/ibd.20453

Review

Lymphocyte homing and its role in the pathogenesis of IBD

Bertus Eksteen et al. Inflamm Bowel Dis. 2008 Sep.

Abstract

Inflammatory bowel disease (IBD) is an idiopathic disorder of chronic inflammation of the gastrointestinal tract. Experimental models of IBD and results from human genomewide linkage studies suggest that the primary defect that leads to IBD is an inappropriate mucosal immune response to normal intestinal microbes. Genetic alterations not only confer increased susceptibility to IBD but also appear to determine the nature and location of the intestinal inflammation, as is evident in patients with genetic alterations of NOD2 and their susceptibility for ileal Crohn's disease. IBD has traditionally been classified into 2 subtypes, namely, ulcerative colitis (UC) and Crohn's disease (CD), based on histological appearance and anatomical distribution. However, an increasing body of data supports the concept that IBD is an umbrella diagnosis encompassing a variety of disorders with distinct genetic, microbial, and environmental determinants that cluster either into a UC or CD phenotype. The shared common pathway is uncontrolled intestinal inflammation. A key element in the pathogenesis of intestinal inflammation in both UC and CD is increased leukocyte recruitment from the circulation, and this provides a potential target for pharmaceutical inhibition. In this article we review the current understanding of the molecules that determine leukocyte trafficking to the gut and highlight opportunities where their inhibition could be exploited to treat IBD.(Inflamm Bowel Dis 2008).

Similar articles

• An Update on Herbal Products for the Management of Inflammatory Bowel Disease.

  Arya H, Dass R, Chopra B, Kriplani P, Deswal G, Singh Grewal A, Dhingra AK, Kumar S. Arya H, et al. Antiinflamm Antiallergy Agents Med Chem. 2023;22(1):1-9. doi: 10.2174/1871523022666230727094250. Antiinflamm Antiallergy Agents Med Chem. 2023. PMID: 37497699 Review.

• Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America.

  North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition; Colitis Foundation of America; Bousvaros A, Antonioli DA, Colletti RB, Dubinsky MC, Glickman JN, Gold BD, Griffiths AM, Jevon GP, Higuchi LM, Hyams JS, Kirschner BS, Kugathasan S, Baldassano RN, Russo PA. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, et al. J Pediatr Gastroenterol Nutr. 2007 May;44(5):653-74. doi: 10.1097/MPG.0b013e31805563f3. J Pediatr Gastroenterol Nutr. 2007. PMID: 17460505

• Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis.

  Saiz-Gonzalo G, Hanrahan N, Rossini V, Singh R, Ahern M, Kelleher M, Hill S, O'Sullivan R, Fanning A, Walsh PT, Hussey S, Shanahan F, Nally K, O'Driscoll CM, Melgar S. Saiz-Gonzalo G, et al. Front Immunol. 2021 Jul 29;12:655960. doi: 10.3389/fimmu.2021.655960. eCollection 2021. Front Immunol. 2021. PMID: 34394073 Free PMC article.

• A galectin-specific signature in the gut delineates Crohn's disease and ulcerative colitis from other human inflammatory intestinal disorders.

  Papa Gobbi R, De Francesco N, Bondar C, Muglia C, Chirdo F, Rumbo M, Rocca A, Toscano MA, Sambuelli A, Rabinovich GA, Docena GH. Papa Gobbi R, et al. Biofactors. 2016 Jan-Feb;42(1):93-105. doi: 10.1002/biof.1252. Epub 2016 Feb 1. Biofactors. 2016. PMID: 26891020

Cited by

• Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease.

  Verstockt B, Vetrano S, Salas A, Nayeri S, Duijvestein M, Vande Casteele N; Alimentiv Translational Research Consortium (ATRC). Verstockt B, et al. Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366. doi: 10.1038/s41575-021-00574-7. Epub 2022 Feb 14. Nat Rev Gastroenterol Hepatol. 2022. PMID: 35165437 Review.

• Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn's Disease: Report of the TOSCA Study.

  D'Haens G, Vermeire S, Vogelsang H, Allez M, Desreumaux P, Van Gossum A, Sandborn WJ, Baumgart DC, Ransohoff RM, Comer GM, Ahmad A, Cataldi F, Cheng J, Clare R, Gorelick KJ, Kaminski A, Pradhan V, Rivers S, Sikpi MO, Zhang Y, Hassan-Zahraee M, Reinisch W, Stuve O. D'Haens G, et al. J Crohns Colitis. 2018 Jan 24;12(2):188-196. doi: 10.1093/ecco-jcc/jjx128. J Crohns Colitis. 2018. PMID: 28961770 Free PMC article.

• Intestinal mononuclear cells primed by systemic interleukin-12 display long-term ability to aggravate colitis in mice.

  Pedrotti LP, Sena AA, Rodriguez Galán MC, Cejas H, Correa SG. Pedrotti LP, et al. Immunology. 2017 Mar;150(3):290-300. doi: 10.1111/imm.12685. Epub 2016 Nov 27. Immunology. 2017. PMID: 27891587 Free PMC article.

• Gut Mesenchymal Stromal Cells in Immunity.

  Messina V, Buccione C, Marotta G, Ziccheddu G, Signore M, Mattia G, Puglisi R, Sacchetti B, Biancone L, Valtieri M. Messina V, et al. Stem Cells Int. 2017;2017:8482326. doi: 10.1155/2017/8482326. Epub 2017 Feb 28. Stem Cells Int. 2017. PMID: 28337224 Free PMC article. Review.

• β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25^hiFoxP3⁺ Regulatory T Cells.

  Sun H, Kuk W, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg MH. Sun H, et al. Cell Mol Gastroenterol Hepatol. 2020;9(3):369-385. doi: 10.1016/j.jcmgh.2019.10.012. Epub 2019 Nov 9. Cell Mol Gastroenterol Hepatol. 2020. PMID: 31707128 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.

• Medical

  • MedlinePlus Health Information