The natural history of type 1A diabetes - PubMed

Review

The natural history of type 1A diabetes

George S Eisenbarth et al. Arq Bras Endocrinol Metabol. 2008 Mar.

Abstract

We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.

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