Maternal herpes simplex virus type 2 coinfection increases the risk of perinatal HIV transmission: possibility to further decrease transmission? - PubMed
- ️Tue Jan 01 2008
Randomized Controlled Trial
. 2008 Jun 19;22(10):1169-76.
doi: 10.1097/QAD.0b013e3282fec42a.
Sara J Whitehead, Philip A Mock, Wanna Leelawiwat, Suvanna Asavapiriyanont, Amphan Chalermchockchareonkit, Nirun Vanprapar, Tawee Chotpitayasunondh, Janet M McNicholl, Jordan W Tappero, Nathan Shaffer, Rutt Chuachoowong
Affiliations
- PMID: 18525263
- DOI: 10.1097/QAD.0b013e3282fec42a
Randomized Controlled Trial
Maternal herpes simplex virus type 2 coinfection increases the risk of perinatal HIV transmission: possibility to further decrease transmission?
Liesbeth Jm Bollen et al. AIDS. 2008.
Abstract
Objectives: To evaluate the association between maternal herpes simplex virus type 2 seropositivity and genital herpes simplex virus type 2 shedding with perinatal HIV transmission.
Study design: Evaluation of women who participated in a 1996-1997 perinatal HIV transmission prevention trial in Thailand.
Methods: In this nonbreastfeeding population, women were randomized to zidovudine or placebo from 36 weeks gestation through delivery; maternal plasma and cervicovaginal HIV viral load and infant HIV status were determined for the original study. Stored maternal plasma and cervicovaginal samples were tested for herpes simplex virus type 2 antibodies by enzyme-linked immunoassay and for herpes simplex virus type 2 DNA by real-time PCR, respectively.
Results: Among 307 HIV-positive women with available samples, 228 (74.3%) were herpes simplex virus type 2 seropositive and 24 (7.8%) were shedding herpes simplex virus type 2. Herpes simplex virus type 2 seropositivity was associated with overall perinatal HIV transmission [adjusted odds ratio, 2.6; 95% confidence interval, 1.0-6.7)], and herpes simplex virus type 2 shedding was associated with intrapartum transmission (adjusted odds ratio, 2.9; 95% confidence interval, 1.0-8.5) independent of plasma and cervicovaginal HIV viral load, and zidovudine treatment. Median plasma HIV viral load was higher among herpes simplex virus type 2 shedders (4.2 vs. 4.1 log(10)copies/ml; P = 0.05), and more shedders had quantifiable levels of HIV in cervicovaginal samples, compared with women not shedding herpes simplex virus type 2 (62.5 vs. 34.3%; P = 0.005).
Conclusion: We found an increased risk of perinatal HIV transmission among herpes simplex virus type 2 seropositive women and an increased risk of intrapartum HIV transmission among women shedding herpes simplex virus type 2. These novel findings suggest that interventions to control herpes simplex virus type 2 infection could further reduce perinatal HIV transmission.
Similar articles
-
Herpes simplex virus type 2 and risk of intrapartum human immunodeficiency virus transmission.
Drake AL, John-Stewart GC, Wald A, Mbori-Ngacha DA, Bosire R, Wamalwa DC, Lohman-Payne BL, Ashley-Morrow R, Corey L, Farquhar C. Drake AL, et al. Obstet Gynecol. 2007 Feb;109(2 Pt 1):403-9. doi: 10.1097/01.AOG.0000251511.27725.5c. Obstet Gynecol. 2007. PMID: 17267842
-
Chuachoowong R, Shaffer N, Siriwasin W, Chaisilwattana P, Young NL, Mock PA, Chearskul S, Waranawat N, Chaowanachan T, Karon J, Simonds RJ, Mastro TD. Chuachoowong R, et al. J Infect Dis. 2000 Jan;181(1):99-106. doi: 10.1086/315179. J Infect Dis. 2000. PMID: 10608756 Clinical Trial.
-
Mofenson LM, Lambert JS, Stiehm ER, Bethel J, Meyer WA 3rd, Whitehouse J, Moye J Jr, Reichelderfer P, Harris DR, Fowler MG, Mathieson BJ, Nemo GJ. Mofenson LM, et al. N Engl J Med. 1999 Aug 5;341(6):385-93. doi: 10.1056/NEJM199908053410601. N Engl J Med. 1999. PMID: 10432323 Clinical Trial.
-
Update on vertical HIV transmission.
Groginsky E, Bowdler N, Yankowitz J. Groginsky E, et al. J Reprod Med. 1998 Aug;43(8):637-46. J Reprod Med. 1998. PMID: 9749412 Review.
-
Preventing perinatal HIV transmission: zidovudine use during pregnancy.
Carmichael C. Carmichael C. Am Fam Physician. 1997 Jan;55(1):171-4, 177-8. Am Fam Physician. 1997. PMID: 9012276 Review.
Cited by
-
Nyiro JU, Sanders EJ, Ngetsa C, Wale S, Awuondo K, Bukusi E, Price MA, Amornkul PN, Nokes DJ. Nyiro JU, et al. BMC Infect Dis. 2011 May 31;11:155. doi: 10.1186/1471-2334-11-155. BMC Infect Dis. 2011. PMID: 21627803 Free PMC article.
-
Barnabas RV, Celum C. Barnabas RV, et al. Curr HIV Res. 2012 Apr;10(3):228-37. doi: 10.2174/157016212800618156. Curr HIV Res. 2012. PMID: 22384842 Free PMC article. Review.
-
Lohman-Payne B, Slyker J, Rowland-Jones SL. Lohman-Payne B, et al. Clin Perinatol. 2010 Dec;37(4):787-805, ix. doi: 10.1016/j.clp.2010.08.005. Clin Perinatol. 2010. PMID: 21078451 Free PMC article.
-
Herpes simplex virus genital infections: current concepts.
Gardella C. Gardella C. Curr Infect Dis Rep. 2011 Dec;13(6):588-94. doi: 10.1007/s11908-011-0209-5. Curr Infect Dis Rep. 2011. PMID: 21861067
-
Does maternal HSV-2 coinfection increase mother-to-child transmission of HIV? A systematic review.
Sivarajah V, Venus K, Yudin MH, Murphy KE, Morrison SA, Tan DH. Sivarajah V, et al. Sex Transm Infect. 2017 Dec;93(8):535-542. doi: 10.1136/sextrans-2016-052921. Epub 2017 Jun 9. Sex Transm Infect. 2017. PMID: 28600331 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical