Common variants of FUT2 are associated with plasma vitamin B12 levels - PubMed

Affiliations

• PMID: 18776911
• PMCID: PMC2673801
• DOI: 10.1038/ng.210

Common variants of FUT2 are associated with plasma vitamin B12 levels

Aditi Hazra et al. Nat Genet. 2008 Oct.

Abstract

We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.

Figures

Similar articles

• Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.

  Hazra A, Kraft P, Lazarus R, Chen C, Chanock SJ, Jacques P, Selhub J, Hunter DJ. Hazra A, et al. Hum Mol Genet. 2009 Dec 1;18(23):4677-87. doi: 10.1093/hmg/ddp428. Epub 2009 Sep 10. Hum Mol Genet. 2009. PMID: 19744961 Free PMC article.

• GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians.

  Nongmaithem SS, Joglekar CV, Krishnaveni GV, Sahariah SA, Ahmad M, Ramachandran S, Gandhi M, Chopra H, Pandit A, Potdar RD, H D Fall C, Yajnik CS, Chandak GR. Nongmaithem SS, et al. Hum Mol Genet. 2017 Jul 1;26(13):2551-2564. doi: 10.1093/hmg/ddx071. Hum Mol Genet. 2017. PMID: 28334792 Free PMC article.

• The FUT2 secretor variant p.Trp154Ter influences serum vitamin B12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation.

  Velkova A, Diaz JEL, Pangilinan F, Molloy AM, Mills JL, Shane B, Sanchez E, Cunningham C, McNulty H, Cropp CD, Bailey-Wilson JE, Wilson AF, Brody LC. Velkova A, et al. Hum Mol Genet. 2017 Dec 15;26(24):4975-4988. doi: 10.1093/hmg/ddx369. Hum Mol Genet. 2017. PMID: 29040465 Free PMC article.

• Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.

  Chery C, Hehn A, Mrabet N, Oussalah A, Jeannesson E, Besseau C, Alberto JM, Gross I, Josse T, Gérard P, Guéant-Rodriguez RM, Freund JN, Devignes J, Bourgaud F, Peyrin-Biroulet L, Feillet F, Guéant JL. Chery C, et al. Biochimie. 2013 May;95(5):995-1001. doi: 10.1016/j.biochi.2013.01.022. Epub 2013 Feb 8. Biochimie. 2013. PMID: 23402911

• The genetics of heart attack.

  Topol EJ. Topol EJ. Heart. 2006 Jun;92(6):855-61. doi: 10.1136/hrt.2005.060202. Heart. 2006. PMID: 16698843 Free PMC article. Review. No abstract available.

Cited by

• Panel 3: Genomics, precision medicine and targeted therapies.

  Santos-Cortez RLP, Bhutta MF, Earl JP, Hafrén L, Jennings M, Mell JC, Pichichero ME, Ryan AF, Tateossian H, Ehrlich GD. Santos-Cortez RLP, et al. Int J Pediatr Otorhinolaryngol. 2020 Mar;130 Suppl 1(Suppl 1):109835. doi: 10.1016/j.ijporl.2019.109835. Epub 2019 Dec 24. Int J Pediatr Otorhinolaryngol. 2020. PMID: 32007292 Free PMC article. Review.

• A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure.

  Frayling TM, Beaumont RN, Jones SE, Yaghootkar H, Tuke MA, Ruth KS, Casanova F, West B, Locke J, Sharp S, Ji Y, Thompson W, Harrison J, Etheridge AS, Gallins PJ, Jima D, Wright F, Zhou Y, Innocenti F, Lindgren CM, Grarup N, Murray A, Freathy RM, Weedon MN, Tyrrell J, Wood AR. Frayling TM, et al. Cell Rep. 2018 Apr 10;23(2):327-336. doi: 10.1016/j.celrep.2018.03.070. Cell Rep. 2018. PMID: 29641994 Free PMC article.

• The Importance of the FUT2 rs602662 Polymorphism in the Risk of Cardiovascular Complications in Patients after Kidney Transplantation.

  Kotowski MJ, Ostrowski P, Sieńko J, Czerny B, Tejchman K, Machaliński B, Górska A, Mrozikiewicz AE, Bogacz A. Kotowski MJ, et al. Int J Mol Sci. 2024 Jun 14;25(12):6562. doi: 10.3390/ijms25126562. Int J Mol Sci. 2024. PMID: 38928269 Free PMC article.

• Intakes of Folate and Vitamin B12 and Biomarkers of Status in the Very Old: The Newcastle 85+ Study.

  Mendonça N, Mathers JC, Adamson AJ, Martin-Ruiz C, Seal CJ, Jagger C, Hill TR. Mendonça N, et al. Nutrients. 2016 Sep 28;8(10):604. doi: 10.3390/nu8100604. Nutrients. 2016. PMID: 27690091 Free PMC article.

• The causal roles of vitamin B(12) and transcobalamin in prostate cancer: can Mendelian randomization analysis provide definitive answers?

  Collin SM, Metcalfe C, Palmer TM, Refsum H, Lewis SJ, Smith GD, Cox A, Davis M, Marsden G, Johnston C, Lane JA, Donovan JL, Neal DE, Hamdy FC, Smith AD, Martin RM. Collin SM, et al. Int J Mol Epidemiol Genet. 2011;2(4):316-27. Epub 2011 Nov 28. Int J Mol Epidemiol Genet. 2011. PMID: 22199995 Free PMC article.

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Nature Publishing Group
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource