Swimming with protists: perception, motility and flagellum assembly - PubMed

Review

Swimming with protists: perception, motility and flagellum assembly

Michael L Ginger et al. Nat Rev Microbiol. 2008 Nov.

Abstract

In unicellular and multicellular eukaryotes, fast cell motility and rapid movement of material over cell surfaces are often mediated by ciliary or flagellar beating. The conserved defining structure in most motile cilia and flagella is the '9+2' microtubule axoneme. Our general understanding of flagellum assembly and the regulation of flagellar motility has been led by results from seminal studies of flagellate protozoa and algae. Here we review recent work relating to various aspects of protist physiology and cell biology. In particular, we discuss energy metabolism in eukaryotic flagella, modifications to the canonical assembly pathway and flagellum function in parasite virulence.

Similar articles

• Coordination of eukaryotic cilia and flagella.

  Wan KY. Wan KY. Essays Biochem. 2018 Dec 7;62(6):829-838. doi: 10.1042/EBC20180029. Print 2018 Dec 7. Essays Biochem. 2018. PMID: 30464007 Free PMC article. Review.

• The conserved ciliary protein Bug22 controls planar beating of Chlamydomonas flagella.

  Meng D, Cao M, Oda T, Pan J. Meng D, et al. J Cell Sci. 2014 Jan 15;127(Pt 2):281-7. doi: 10.1242/jcs.140723. Epub 2013 Nov 20. J Cell Sci. 2014. PMID: 24259666

• A natural toroidal microswimmer with a rotary eukaryotic flagellum.

  Hess S, Eme L, Roger AJ, Simpson AGB. Hess S, et al. Nat Microbiol. 2019 Oct;4(10):1620-1626. doi: 10.1038/s41564-019-0478-6. Epub 2019 Jun 10. Nat Microbiol. 2019. PMID: 31182800

• Trypanosoma, Paramecium and Tetrahymena: From genomics to flagellar and ciliary structures and cytoskeleton dynamics.

  Soares H, Sunter JD, Wloga D, Joachimiak E, Miceli C. Soares H, et al. Eur J Protistol. 2020 Oct;76:125722. doi: 10.1016/j.ejop.2020.125722. Epub 2020 Jun 10. Eur J Protistol. 2020. PMID: 32679518 Review.

• Complex flagellar motions and swimming patterns of the flagellates Paraphysomonas vestita and Pteridomonas danica.

  Christensen-Dalsgaard KK, Fenchel T. Christensen-Dalsgaard KK, et al. Protist. 2004 Mar;155(1):79-87. doi: 10.1078/1434461000166. Protist. 2004. PMID: 15144060

Cited by

• Parasites in motion: flagellum-driven cell motility in African trypanosomes.

  Hill KL. Hill KL. Curr Opin Microbiol. 2010 Aug;13(4):459-65. doi: 10.1016/j.mib.2010.05.015. Epub 2010 Jun 28. Curr Opin Microbiol. 2010. PMID: 20591724 Free PMC article. Review.

• Structure of Trypanosoma brucei flagellum accounts for its bihelical motion.

  Koyfman AY, Schmid MF, Gheiratmand L, Fu CJ, Khant HA, Huang D, He CY, Chiu W. Koyfman AY, et al. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11105-8. doi: 10.1073/pnas.1103634108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690369 Free PMC article.

• Optical trapping reveals propulsion forces, power generation and motility efficiency of the unicellular parasites Trypanosoma brucei brucei.

  Stellamanns E, Uppaluri S, Hochstetter A, Heddergott N, Engstler M, Pfohl T. Stellamanns E, et al. Sci Rep. 2014 Oct 1;4:6515. doi: 10.1038/srep06515. Sci Rep. 2014. PMID: 25269514 Free PMC article.

• Tsetse fly saliva: Could it be useful in fly infection when feeding in chronically aparasitemic mammalian hosts.

  Awuoche EO. Awuoche EO. Open Vet J. 2012;2(1):95-105. Epub 2012 Sep 30. Open Vet J. 2012. PMID: 26623300 Free PMC article. Review.

• Both sequence and context are important for flagellar targeting of a glucose transporter.

  Tran KD, Rodriguez-Contreras D, Shinde U, Landfear SM. Tran KD, et al. J Cell Sci. 2012 Jul 15;125(Pt 14):3293-8. doi: 10.1242/jcs.103028. Epub 2012 Mar 30. J Cell Sci. 2012. PMID: 22467850 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group