Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications - PubMed
- ️Thu Jan 01 2009
. 2009 Mar 1;15(5):1779-86.
doi: 10.1158/1078-0432.CCR-08-1463. Epub 2009 Feb 17.
Jeroen J Mooren, Martin Lehnen, Sandra M H Claessen, Markus Stenner, Christian U Huebbers, Soenke J Weissenborn, Inga Wedemeyer, Simon F Preuss, Jos M J A A Straetmans, Johannes J Manni, Anton H N Hopman, Ernst-Jan M Speel
Affiliations
- PMID: 19223504
- DOI: 10.1158/1078-0432.CCR-08-1463
Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications
Jens P Klussmann et al. Clin Cancer Res. 2009.
Abstract
Purpose: Patients with human papillomavirus (HPV)-containing oropharyngeal squamous cell carcinomas (OSCC) have a better prognosis than patients with HPV-negative OSCC. This may be attributed to different genetic pathways promoting cancer.
Experimental design: We used comparative genomic hybridization to identify critical genetic changes in 60 selected OSCC, 28 of which were associated with HPV-16 as determined by HPV-specific PCR and fluorescence in situ hybridization analysis and positive p16(INK4A) immunostaining. The results were correlated with HPV status and clinical data from patients.
Results: Two thirds of OSCC harbored gain at 3q26.3-qter irrespective of HPV status. In HPV-negative tumors this alteration was associated with advanced tumor stage (P=0.013). In comparison with HPV-related OSCC, the HPV-negative tumors harbored: (a) a higher number of chromosomal alterations and amplifications (P=0.03 and 0.039, respectively); (b) significantly more losses at 3p, 5q, 9p, 15q, and 18q, and gains/amplifications at 11q13 (P=0.002, 0.03; <0.001, 0.02, 0.004, and 0.001, respectively); and (c) less often 16q losses and Xp gains (P=0.02 and 0.03). Survival analysis revealed a significantly better disease-free survival for HPV-related OSCC (P=0.02), whereas chromosome amplification was an unfavorable prognostic indicator for disease-free and overall survival (P=0.01 and 0.05, respectively). Interestingly, 16q loss, predominantly identified in HPV-related OSCC, was a strong indicator of favorable outcome (overall survival, P=0.008; disease-free survival, P=0.01) and none of these patients had a tumor recurrence.
Conclusions: Genetic signatures of HPV-related and HPV-unrelated OSCC are different and most likely underlie differences in tumor development and progression. In addition, distinct chromosomal alterations have prognostic significance.
Similar articles
-
Laco J, Nekvindova J, Novakova V, Celakovsky P, Dolezalova H, Tucek L, Vosmikova H, Vosmik M, Neskudlova T, Cermakova E, Hacova M, Sobande FA, Ryska A. Laco J, et al. Neoplasma. 2012;59(4):398-408. doi: 10.4149/neo_2012_052. Neoplasma. 2012. PMID: 22489695
-
Weinberger PM, Yu Z, Kountourakis P, Sasaki C, Haffty BG, Kowalski D, Merkley MA, Rimm DL, Camp RL, Psyrri A. Weinberger PM, et al. Otolaryngol Head Neck Surg. 2009 Sep;141(3):382-9. doi: 10.1016/j.otohns.2009.04.014. Otolaryngol Head Neck Surg. 2009. PMID: 19716018
-
Shaw R, Robinson M. Shaw R, et al. Br J Oral Maxillofac Surg. 2011 Sep;49(6):423-9. doi: 10.1016/j.bjoms.2010.06.023. Epub 2010 Aug 19. Br J Oral Maxillofac Surg. 2011. PMID: 20727631 Review.
-
Psyrri A, Prezas L, Burtness B. Psyrri A, et al. Clin Adv Hematol Oncol. 2008 Aug;6(8):604-12. Clin Adv Hematol Oncol. 2008. PMID: 18820604 Review.
Cited by
-
Hooper JE, Hebert JF, Schilling A, Gross ND, Schindler JS, Lagowski JP, Kulesz-Martin M, Corless CL, Morgan TK. Hooper JE, et al. Appl Immunohistochem Mol Morphol. 2015 Apr;23(4):266-72. doi: 10.1097/PDM.0000000000000036. Appl Immunohistochem Mol Morphol. 2015. PMID: 25839700 Free PMC article.
-
The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma.
Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Okamoto Y, Seki N. Koshizuka K, et al. J Hum Genet. 2017 Jan;62(1):3-13. doi: 10.1038/jhg.2016.105. Epub 2016 Aug 25. J Hum Genet. 2017. PMID: 27557665 Review.
-
Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis.
Swarts DRA, Voorham QJM, van Splunter AP, Wilting SM, Sie D, Pronk D, van Beurden M, Heideman DAM, Snijders PJF, Meijer CJLM, Steenbergen RDM, Bleeker MCG. Swarts DRA, et al. Cancer Med. 2018 Sep;7(9):4542-4553. doi: 10.1002/cam4.1633. Epub 2018 Jul 20. Cancer Med. 2018. PMID: 30030907 Free PMC article.
-
Reuschenbach M, Wagner S, Würdemann N, Sharma SJ, Prigge ES, Sauer M, Wittig A, Wittekindt C, von Knebel Doeberitz M, Klussmann JP. Reuschenbach M, et al. HNO. 2016 Jul;64(7):450-9. doi: 10.1007/s00106-016-0123-0. HNO. 2016. PMID: 26864190 Review. German.
-
Rhie A, Park WS, Choi MK, Kim JH, Ryu J, Ryu CH, Kim JI, Jung YS. Rhie A, et al. Medicine (Baltimore). 2015 Dec;94(50):e2187. doi: 10.1097/MD.0000000000002187. Medicine (Baltimore). 2015. PMID: 26683928 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources