Midlatency auditory evoked responses in schizophrenia - PubMed

Midlatency auditory evoked responses in schizophrenia

R J Erwin et al. Biol Psychiatry. 1991.

Free article

Abstract

The auditory evoked component P50 has been reported as having an abnormal recovery cycle in patients with schizophrenia. Recent studies examining the effects of stimulus rate on the midlatency response (MLR) component P1, found P1 recovery cycles in normals similar to P50. This study examined the P1 recovery cycle in patients using a rate protocol and MLR recording procedures. MLRs were recorded from 13 controls and 13 patients with schizophrenia in response to binaurally presented clicks presented at three stimulus rates: 0.9/sec, 5.1/sec, and 9.9/sec. The P1 (50-70 msec latency) in patients did not decrease as much in amplitude as in controls at the 9.9/sec stimulus rate. This lack of recovery was correlated with clinical ratings of symptomatology. Since evidence from both the human and the cat model suggests that the P1 is generated in thalamus, these findings are consistent with reports of thalamic dysfunction in schizophrenia.

Similar articles

• Effects of medication history on midlatency auditory evoked responses in schizophrenia.

  Erwin RJ, Shtasel D, Gur RE. Erwin RJ, et al. Schizophr Res. 1994 Feb;11(3):251-8. doi: 10.1016/0920-9964(94)90019-1. Schizophr Res. 1994. PMID: 7910754

• P50 abnormalities in schizophrenia: relationship to clinical and neuropsychological indices of attention.

  Erwin RJ, Turetsky BI, Moberg P, Gur RC, Gur RE. Erwin RJ, et al. Schizophr Res. 1998 Oct 9;33(3):157-67. doi: 10.1016/s0920-9964(98)00075-9. Schizophr Res. 1998. PMID: 9789908

• Event-related potential abnormalities correlate with structural brain alterations and clinical features in patients with chronic schizophrenia.

  Egan MF, Duncan CC, Suddath RL, Kirch DG, Mirsky AF, Wyatt RJ. Egan MF, et al. Schizophr Res. 1994 Feb;11(3):259-71. doi: 10.1016/0920-9964(94)90020-5. Schizophr Res. 1994. PMID: 7910755

• [Event-related potentials in psychiatry--methodologic principles].

  Münte F, Künkel H. Münte F, et al. Psychiatr Neurol Med Psychol (Leipz). 1990 Nov;42(11):649-59. Psychiatr Neurol Med Psychol (Leipz). 1990. PMID: 2093195 Review. German.

• The neuropsychology of schizophrenia: relations with clinical and neurobiological dimensions.

  Elliott R, Sahakian BJ. Elliott R, et al. Psychol Med. 1995 May;25(3):581-94. doi: 10.1017/s0033291700033493. Psychol Med. 1995. PMID: 7480438 Review. No abstract available.

Cited by

• Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alpha.

  Gould TJ, Bizily SP, Tokarczyk J, Kelly MP, Siegel SJ, Kanes SJ, Abel T. Gould TJ, et al. Neuropsychopharmacology. 2004 Mar;29(3):494-501. doi: 10.1038/sj.npp.1300309. Neuropsychopharmacology. 2004. PMID: 14694347 Free PMC article.

• Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients.

  Zhang J, Abdallah CG, Wang J, Wan X, Liang C, Jiang L, Liu Y, Huang H, Hong X, Huang Q, Wu R, Xu C. Zhang J, et al. Psychiatry Res. 2012 Dec 30;200(2-3):126-32. doi: 10.1016/j.psychres.2012.04.021. Epub 2012 Jun 16. Psychiatry Res. 2012. PMID: 22705363 Free PMC article.

• Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia.

  Olincy A, Braff DL, Adler LE, Cadenhead KS, Calkins ME, Dobie DJ, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, Mintz J, Nuechterlein KH, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Wagner BD, Freedman R. Olincy A, et al. Schizophr Res. 2010 Jun;119(1-3):175-82. doi: 10.1016/j.schres.2010.03.004. Epub 2010 Apr 10. Schizophr Res. 2010. PMID: 20382002 Free PMC article.

• Noradrenergic antagonism of the P13 and N40 components of the rat auditory evoked potential.

  Keedy SK, Marlow-O'Connor M, Beenken B, Dorflinger J, Abel M, Erwin RJ. Keedy SK, et al. Psychopharmacology (Berl). 2007 Jan;190(1):117-25. doi: 10.1007/s00213-006-0608-8. Epub 2006 Nov 10. Psychopharmacology (Berl). 2007. PMID: 17096083

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal