How cigarette smoke skews immune responses to promote infection, lung disease and cancer - PubMed

Affiliations

• PMID: 19330016
• DOI: 10.1038/nri2530

Review

How cigarette smoke skews immune responses to promote infection, lung disease and cancer

Martin R Stämpfli et al. Nat Rev Immunol. 2009 May.

Abstract

A complex and multilayered immune defence system protects the host against harmful agents and maintains tissue homeostasis. Cigarette smoke exposure markedly impacts the immune system, compromising the host's ability to mount appropriate immune and inflammatory responses and contributing to smoking-related pathologies. These adverse effects on the immune system not only occur in active smokers, but also in those exposed to smoke passively in contaminated environments, and may persist for decades after exposure has ended.

Similar articles

• Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?

  Qiu F, Liang CL, Liu H, Zeng YQ, Hou S, Huang S, Lai X, Dai Z. Qiu F, et al. Oncotarget. 2017 Jan 3;8(1):268-284. doi: 10.18632/oncotarget.13613. Oncotarget. 2017. PMID: 27902485 Free PMC article. Review.

• The influence of cigarette smoking on viral infections: translating bench science to impact COPD pathogenesis and acute exacerbations of COPD clinically.

  Bauer CMT, Morissette MC, Stämpfli MR. Bauer CMT, et al. Chest. 2013 Jan;143(1):196-206. doi: 10.1378/chest.12-0930. Chest. 2013. PMID: 23276842 Review.

• Cigarette smoke-induced inflammation and respiratory host defense: Insights from animal models.

  Nikota JK, Stämpfli MR. Nikota JK, et al. Pulm Pharmacol Ther. 2012 Aug;25(4):257-62. doi: 10.1016/j.pupt.2012.05.005. Epub 2012 May 24. Pulm Pharmacol Ther. 2012. PMID: 22634304 Review.

• Cigarette smoke, inflammation, and lung injury: a mechanistic perspective.

  Bhalla DK, Hirata F, Rishi AK, Gairola CG. Bhalla DK, et al. J Toxicol Environ Health B Crit Rev. 2009 Jan;12(1):45-64. doi: 10.1080/10937400802545094. J Toxicol Environ Health B Crit Rev. 2009. PMID: 19117209 Review.

• Increased Myeloid Cell Production and Lung Bacterial Clearance in Mice Exposed to Cigarette Smoke.

  Basilico P, Cremona TP, Oevermann A, Piersigilli A, Benarafa C. Basilico P, et al. Am J Respir Cell Mol Biol. 2016 Mar;54(3):424-35. doi: 10.1165/rcmb.2015-0017OC. Am J Respir Cell Mol Biol. 2016. PMID: 26273827

Cited by

• Inflammatory transcriptome profiling of human monocytes exposed acutely to cigarette smoke.

  Wright WR, Parzych K, Crawford D, Mein C, Mitchell JA, Paul-Clark MJ. Wright WR, et al. PLoS One. 2012;7(2):e30120. doi: 10.1371/journal.pone.0030120. Epub 2012 Feb 17. PLoS One. 2012. PMID: 22363418 Free PMC article.

• Effects of cigarette smoke extract on primary activated T cells.

  Hernandez CP, Morrow K, Velasco C, Wyczechowska DD, Naura AS, Rodriguez PC. Hernandez CP, et al. Cell Immunol. 2013 Mar;282(1):38-43. doi: 10.1016/j.cellimm.2013.04.005. Epub 2013 Apr 22. Cell Immunol. 2013. PMID: 23665673 Free PMC article.

• Cigarette smoke increases Staphylococcus aureus biofilm formation via oxidative stress.

  Kulkarni R, Antala S, Wang A, Amaral FE, Rampersaud R, Larussa SJ, Planet PJ, Ratner AJ. Kulkarni R, et al. Infect Immun. 2012 Nov;80(11):3804-11. doi: 10.1128/IAI.00689-12. Epub 2012 Aug 13. Infect Immun. 2012. PMID: 22890993 Free PMC article.

• Differential effects of environmental exposures on clinically relevant endophenotypes between sexes.

  González Zarzar T, Palmiero NE, Kim D, Shen L, Hall MA. González Zarzar T, et al. Sci Rep. 2024 Sep 13;14(1):21453. doi: 10.1038/s41598-024-72180-x. Sci Rep. 2024. PMID: 39271740 Free PMC article.

• Haemophilus influenzae persists in biofilm communities in a smoke-exposed ferret model of COPD.

  Hunt BC, Stanford D, Xu X, Li J, Gaggar A, Rowe SM, Raju SV, Swords WE. Hunt BC, et al. ERJ Open Res. 2020 Aug 11;6(3):00200-2020. doi: 10.1183/23120541.00200-2020. eCollection 2020 Jul. ERJ Open Res. 2020. PMID: 32802827 Free PMC article.

References

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Medical

  • MedlinePlus Health Information