Humoral immunity to respiratory syncytial virus in young and elderly adults - PubMed

Affiliations

• PMID: 19366492
• DOI: 10.1017/S0950268809002593

Humoral immunity to respiratory syncytial virus in young and elderly adults

C Terrosi et al. Epidemiol Infect. 2009 Dec.

Abstract

Respiratory syncytial virus (RSV) has been demonstrated to cause substantial disease in elderly and immunocompromised subjects. The relationship of serum antibody to RSV infection and the risk of infection in elderly subjects is controversial, thus we evaluated the presence of neutralizing antibodies to RSV in healthy people of different age groups and the correlation with viral protection. Baseline blood samples from 197 subjects aged 20-80 years were analysed for the presence of anti-RSV antibodies either by indirect immunofluorescence and microneutralization test. The percentage of people who had neutralizing antibodies to RSV was significantly higher (P=0.001) in the youngest group (92.51%) compared to the frail group (36.21%). The RSV antibody level tends to wane in some older people; this factor could determine proneness to RSV re-infections in the elderly who are at a greater risk of developing severe respiratory disease.

Similar articles

• Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults.

  Walsh EE, Falsey AR. Walsh EE, et al. J Infect Dis. 2004 Jul 15;190(2):373-8. doi: 10.1086/421524. Epub 2004 Jun 18. J Infect Dis. 2004. PMID: 15216475

• Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique.

  Roca A, Abacassamo F, Loscertales MP, Quintó L, Gómez-Olivé X, Fenwick F, Saiz JC, Toms G, Alonso PL. Roca A, et al. J Med Virol. 2002 Aug;67(4):616-23. doi: 10.1002/jmv.10148. J Med Virol. 2002. PMID: 12116014

• Young infants can develop protective levels of neutralizing antibody after infection with respiratory syncytial virus.

  Shinoff JJ, O'Brien KL, Thumar B, Shaw JB, Reid R, Hua W, Santosham M, Karron RA. Shinoff JJ, et al. J Infect Dis. 2008 Oct 1;198(7):1007-15. doi: 10.1086/591460. J Infect Dis. 2008. PMID: 18702606

• Respiratory syncytial virus infection in adults.

  Falsey AR. Falsey AR. Semin Respir Crit Care Med. 2007 Apr;28(2):171-81. doi: 10.1055/s-2007-976489. Semin Respir Crit Care Med. 2007. PMID: 17458771 Review.

• Passive antibody prophylaxis for RSV.

  DeVincenzo J. DeVincenzo J. Pediatr Infect Dis J. 2008 Jan;27(1):69-70. doi: 10.1097/INF.0b013e318160921e. Pediatr Infect Dis J. 2008. PMID: 18162943 Review. No abstract available.

Cited by

• Seroprevalence of human respiratory syncytial virus and human metapneumovirus in healthy population analyzed by recombinant fusion protein-based enzyme linked immunosorbent assay.

  Sastre P, Ruiz T, Schildgen O, Schildgen V, Vela C, Rueda P. Sastre P, et al. Virol J. 2012 Jul 2;9:130. doi: 10.1186/1743-422X-9-130. Virol J. 2012. PMID: 22748150 Free PMC article.

• A prospective surveillance study on the kinetics of the humoral immune response to the respiratory syncytial virus fusion protein in adults in Houston, Texas.

  Blunck BN, Aideyan L, Ye X, Avadhanula V, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA. Blunck BN, et al. Vaccine. 2021 Feb 22;39(8):1248-1256. doi: 10.1016/j.vaccine.2021.01.045. Epub 2021 Jan 26. Vaccine. 2021. PMID: 33509697 Free PMC article.

• Utilization of serologic assays to support efficacy of vaccines in nonclinical and clinical trials: meeting at the crossroads.

  Madore DV, Meade BD, Rubin F, Deal C, Lynn F; Meeting Contributors. Madore DV, et al. Vaccine. 2010 Jun 23;28(29):4539-47. doi: 10.1016/j.vaccine.2010.04.094. Epub 2010 May 12. Vaccine. 2010. PMID: 20470795 Free PMC article.

• Respiratory syncytial virus infections in the adult asthmatic--mechanisms of host susceptibility and viral subversion.

  Westerly BD, Peebles RS Jr. Westerly BD, et al. Immunol Allergy Clin North Am. 2010 Nov;30(4):523-39, vi-vii. doi: 10.1016/j.iac.2010.08.006. Epub 2010 Sep 22. Immunol Allergy Clin North Am. 2010. PMID: 21029936 Free PMC article. Review.

• RSV and HMPV seroprevalence in Tuscany (Italy) and North-Rhine Westfalia (Germany) in the winter season 2009/2010.

  Cusi MG, Terrosi C, Kleines M, Schildgen O. Cusi MG, et al. Influenza Other Respir Viruses. 2011 Nov;5(6):380-1. doi: 10.1111/j.1750-2659.2011.00252.x. Epub 2011 Apr 18. Influenza Other Respir Viruses. 2011. PMID: 21668674 Free PMC article. No abstract available.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Cambridge University Press
  • Ovid Technologies, Inc.