Delivery of peptide and protein drugs over the blood-brain barrier - PubMed

Review

Delivery of peptide and protein drugs over the blood-brain barrier

Ivona Brasnjevic et al. Prog Neurobiol. 2009 Apr.

Abstract

Peptide and protein (P/P) drugs have been identified as showing great promises for the treatment of various neurodegenerative diseases. A major challenge in this regard, however, is the delivery of P/P drugs over the blood-brain barrier (BBB). Intense research over the last 25 years has enabled a better understanding of the cellular and molecular transport mechanisms at the BBB, and several strategies for enhanced P/P drug delivery over the BBB have been developed and tested in preclinical and clinical-experimental research. Among them, technology-based approaches (comprising functionalized nanocarriers and liposomes) and pharmacological strategies (such as the use of carrier systems and chimeric peptide technology) appear to be the most promising ones. This review combines a comprehensive overview on the current understanding of the transport mechanisms at the BBB with promising selected strategies published so far that can be applied to facilitate enhanced P/P drug delivery over the BBB.

Similar articles

• Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?

  Garcia-Garcia E, Andrieux K, Gil S, Couvreur P. Garcia-Garcia E, et al. Int J Pharm. 2005 Jul 25;298(2):274-92. doi: 10.1016/j.ijpharm.2005.03.031. Int J Pharm. 2005. PMID: 15896933 Review.

• Active targeting of brain tumors using nanocarriers.

  Béduneau A, Saulnier P, Benoit JP. Béduneau A, et al. Biomaterials. 2007 Nov;28(33):4947-67. doi: 10.1016/j.biomaterials.2007.06.011. Epub 2007 Aug 22. Biomaterials. 2007. PMID: 17716726 Review.

• Opioid peptide drug development: transport of opioid chimeric peptides through the blood-brain barrier.

  Pardridge WM. Pardridge WM. NIDA Res Monogr. 1992;120:153-68. NIDA Res Monogr. 1992. PMID: 1501684 Review.

• Drug delivery to the CNS and polymeric nanoparticulate carriers.

  Costantino L. Costantino L. Future Med Chem. 2010 Nov;2(11):1681-701. doi: 10.4155/fmc.10.249. Future Med Chem. 2010. PMID: 21428839 Review.

• Molecular Trojan horses for blood-brain barrier drug delivery.

  Pardridge WM. Pardridge WM. Curr Opin Pharmacol. 2006 Oct;6(5):494-500. doi: 10.1016/j.coph.2006.06.001. Epub 2006 Jul 12. Curr Opin Pharmacol. 2006. PMID: 16839816 Review.

Cited by

• TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid-β Neuropathology via Akt/Gsk3β-Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model.

  Wang X, Bian Y, Wong CTT, Lu JH, Lee SM. Wang X, et al. Oxid Med Cell Longev. 2022 Aug 27;2022:1544244. doi: 10.1155/2022/1544244. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36065437 Free PMC article.

• Targeted delivery of nano-therapeutics for major disorders of the central nervous system.

  Gao H, Pang Z, Jiang X. Gao H, et al. Pharm Res. 2013 Oct;30(10):2485-98. doi: 10.1007/s11095-013-1122-4. Pharm Res. 2013. PMID: 23797465 Review.

• A Nanobody-Mediated Virus-Targeting Drug Delivery Platform for the Central Nervous System Viral Disease Therapy.

  Zhu S, Luo F, Zhu B, Ling F, Wang EL, Liu TQ, Wang GX. Zhu S, et al. Microbiol Spectr. 2021 Dec 22;9(3):e0148721. doi: 10.1128/Spectrum.01487-21. Epub 2021 Nov 24. Microbiol Spectr. 2021. PMID: 34817277 Free PMC article.

• Research Progress of Neutrophil-Mediated Drug Delivery Strategies for Inflammation-Related Disease.

  Zhao Y, Zhang H, Zhang Q, Tao H. Zhao Y, et al. Pharmaceutics. 2023 Jul 4;15(7):1881. doi: 10.3390/pharmaceutics15071881. Pharmaceutics. 2023. PMID: 37514067 Free PMC article. Review.

• Apolipoprotein A-I Crosses the Blood-Brain Barrier through Clathrin-Independent and Cholesterol-Mediated Endocytosis.

  Zhou AL, Swaminathan SK, Curran GL, Poduslo JF, Lowe VJ, Li L, Kandimalla KK. Zhou AL, et al. J Pharmacol Exp Ther. 2019 Jun;369(3):481-488. doi: 10.1124/jpet.118.254201. Epub 2019 Apr 10. J Pharmacol Exp Ther. 2019. PMID: 30971477 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal