Fatal metformin overdose presenting with progressive hyperglycemia - PubMed

Fatal metformin overdose presenting with progressive hyperglycemia

Jeffrey R Suchard et al. West J Emerg Med. 2008 Aug.

Abstract

A 29-year-old man with no history of diabetes ingested over 60 grams of metformin in a suicide attempt. He presented to the emergency department with acute renal insufficiency, severe lactic acidosis, and rapidly-progressive hyperglycemia. The patient's peak serum glucose level of 707 mg/dL is the highest yet reported in a case of metformin toxicity. Treatment included sodium bicarbonate infusion and hemodialysis, but the patient suffered several cardiac arrests with pulseless electrical activity and ultimately expired 25 hours after the ingestion.

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