Primary structure of keratinocyte transglutaminase - PubMed

Comparative Study

Primary structure of keratinocyte transglutaminase

M A Phillips et al. Proc Natl Acad Sci U S A. 1990 Dec.

Abstract

The nucleotide and deduced amino acid sequences of the coding regions of human and rat keratinocyte transglutaminases (protein-glutamine: amine gamma-glutamyltransferase; EC 2.3.2.13) have been determined. These yield proteins of approximately 90 kDa that are 92% identical, indicative of the conservation of important structural features. Alignments of amino acid sequences show substantial similarity among the keratinocyte transglutaminase, human clotting factor XIII catalytic subunit, guinea pig liver tissue transglutaminase, and the human erythrocyte band-4.2 protein. The keratinocyte enzyme is most similar to factor XIII, whereas the band-4.2 protein is most similar to the tissue transglutaminase. A salient feature of the keratinocyte transglutaminase is its 105-residue extension beyond the N terminus of the tissue transglutaminase. This extension and the unrelated activation peptide of factor XIII (a 37-residue extension) appear to be added for specialized functions after divergence of the tissue transglutaminase from their common lineage.

Similar articles

• Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.

  Yamanishi K, Liew FM, Konishi K, Yasuno H, Doi H, Hirano J, Fukushima S. Yamanishi K, et al. Biochem Biophys Res Commun. 1991 Mar 29;175(3):906-13. doi: 10.1016/0006-291x(91)91651-r. Biochem Biophys Res Commun. 1991. PMID: 1673840

• Organization and evolution of the human epidermal keratinocyte transglutaminase I gene.

  Polakowska RR, Eickbush T, Falciano V, Razvi F, Goldsmith LA. Polakowska RR, et al. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4476-80. doi: 10.1073/pnas.89.10.4476. Proc Natl Acad Sci U S A. 1992. PMID: 1350092 Free PMC article.

• Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues.

  Greenberg CS, Birckbichler PJ, Rice RH. Greenberg CS, et al. FASEB J. 1991 Dec;5(15):3071-7. doi: 10.1096/fasebj.5.15.1683845. FASEB J. 1991. PMID: 1683845 Review.

• Keratinocyte transglutaminase: differentiation marker and member of an extended family.

  Rice RH, Mehrpouyan M, O'Callahan W, Parenteau NL, Rubin AL. Rice RH, et al. Epithelial Cell Biol. 1992 Jul;1(3):128-37. Epithelial Cell Biol. 1992. PMID: 1364041 Review.

Cited by

• New nucleotide sequence data on the EMBL File Server.

  [No authors listed] [No authors listed] Nucleic Acids Res. 1991 Apr 11;19(7):1731-6. doi: 10.1093/nar/19.7.1731. Nucleic Acids Res. 1991. PMID: 2027787 Free PMC article. No abstract available.

• Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer.

  Cho SY, Choi K, Jeon JH, Kim CW, Shin DM, Lee JB, Lee SE, Kim CS, Park JS, Jeong EM, Jang GY, Song KY, Kim IG. Cho SY, et al. Exp Mol Med. 2010 Apr 30;42(4):310-8. doi: 10.3858/emm.2010.42.4.031. Exp Mol Med. 2010. PMID: 20177144 Free PMC article.

• Transcription factor Sp1 activates involucrin promoter activity in non-epithelial cell types.

  Banks EB, Crish JF, Eckert RL. Banks EB, et al. Biochem J. 1999 Feb 1;337 ( Pt 3)(Pt 3):507-12. Biochem J. 1999. PMID: 9895295 Free PMC article.

• Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesion.

  Gentile V, Thomazy V, Piacentini M, Fesus L, Davies PJ. Gentile V, et al. J Cell Biol. 1992 Oct;119(2):463-74. doi: 10.1083/jcb.119.2.463. J Cell Biol. 1992. PMID: 1356992 Free PMC article.

• Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase).

  Matsuki M, Yamashita F, Ishida-Yamamoto A, Yamada K, Kinoshita C, Fushiki S, Ueda E, Morishima Y, Tabata K, Yasuno H, Hashida M, Iizuka H, Ikawa M, Okabe M, Kondoh G, Kinoshita T, Takeda J, Yamanishi K. Matsuki M, et al. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1044-9. doi: 10.1073/pnas.95.3.1044. Proc Natl Acad Sci U S A. 1998. PMID: 9448282 Free PMC article.

References

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource