pubmed.ncbi.nlm.nih.gov

Mizoribine: a new approach in the treatment of renal disease - PubMed

Review

Mizoribine: a new approach in the treatment of renal disease

Yukihiko Kawasaki. Clin Dev Immunol. 2009.

Abstract

Mizoribine (MZB) is an imidazole nucleoside and an immunosuppressive agent. The immunosuppressive effect of MZB has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. Because of its relative lack of toxicity, during the past decade MZB has been frequently used instead of azathioprine as a component of immunosuppressive drug regimens. MZB is being used to treat renal transplantation patients, IgA nephropathy, lupus erythematosus, and childhood nephrotic syndrome (NS), and some recent studies have assessed the efficacy of oral MZB pulse therapy for severe lupus nephritis, steroid-resistant NS, and frequently relapsing-steroid-dependent NS. This review summarizes the published findings on the efficacy of MZB for renal disease including IgA nephropathy, lupus nephritis, and NS, as well as of oral MZB pulse therapy for severe lupus nephritis and NS, and also the mechanism of the effect of oral MZB pulse therapy on the lymphocyte cell cycle.

PubMed Disclaimer

Figures

Figure 1
Figure 1

Change in the serum MZB concentration of each patient on the days when MZB was administered.

Similar articles

Cited by

References

    1. Mizuno K, Tsujino M, Takada M, Hayashi M, Atsumi K. Studies on bredinin. I. Isolation, characterization and biological properties. Journal of Antibiotics. 1974;27(10):775–782. - PubMed
    1. Kamata K, Okubo M, Ishigamori E, et al. Immunosuppressive effect of bredinin on cell-mediated and humoral immune reactions in experimental animals. Transplantation. 1983;35(2):144–149. - PubMed
    1. Ichikawa Y, Ihara H, Takahara S. The immunosuppressive mode of action of mizoribine. Transplantation. 1984;38(3):262–267. - PubMed
    1. Ishikawa H. Mizoribine and mycophenolate mofetil. Current Medicinal Chemistry. 1999;6(7):575–597. - PubMed
    1. Hamasaki T, Mori M, Kinoshita Y, Saeki T, Sakano T. Mizoribine in steroid-dependent nephrotic syndrome of childhood. Pediatric Nephrology. 1997;11(5):625–627. - PubMed

Publication types

MeSH terms

Substances