Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009 - PubMed

Affiliations

• PMID: 20196795
• DOI: 10.1111/j.1528-1167.2010.02522.x

Free article

Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009

Anne T Berg et al. Epilepsia. 2010 Apr.

Free article

Abstract

The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy. Generalized and focal are redefined for seizures as occurring in and rapidly engaging bilaterally distributed networks (generalized) and within networks limited to one hemisphere and either discretely localized or more widely distributed (focal). Classification of generalized seizures is simplified. No natural classification for focal seizures exists; focal seizures should be described according to their manifestations (e.g., dyscognitive, focal motor). The concepts of generalized and focal do not apply to electroclinical syndromes. Genetic, structural-metabolic, and unknown represent modified concepts to replace idiopathic, symptomatic, and cryptogenic. Not all epilepsies are recognized as electroclinical syndromes. Organization of forms of epilepsy is first by specificity: electroclinical syndromes, nonsyndromic epilepsies with structural-metabolic causes, and epilepsies of unknown cause. Further organization within these divisions can be accomplished in a flexible manner depending on purpose. Natural classes (e.g., specific underlying cause, age at onset, associated seizure type), or pragmatic groupings (e.g., epileptic encephalopathies, self-limited electroclinical syndromes) may serve as the basis for organizing knowledge about recognized forms of epilepsy and facilitate identification of new forms.

Comment in

• Terminology and organization of seizures and epilepsies: radical changes not justified by new evidence.

  Ferrie CD. Ferrie CD. Epilepsia. 2010 Apr;51(4):713-4. doi: 10.1111/j.1528-1167.2010.02540.x. Epilepsia. 2010. PMID: 20394642 No abstract available.

• What is a classification essay?

  Fisher RS. Fisher RS. Epilepsia. 2010 Apr;51(4):714-5. doi: 10.1111/j.1528-1167.2010.02541.x. Epilepsia. 2010. PMID: 20394643 No abstract available.

• The new ILAE classification.

  Shinnar S. Shinnar S. Epilepsia. 2010 Apr;51(4):715-7. doi: 10.1111/j.1528-1167.2010.02542.x. Epilepsia. 2010. PMID: 20394644 No abstract available.

• Much ado about nothing?

  Wolf P. Wolf P. Epilepsia. 2010 Apr;51(4):717-8. doi: 10.1111/j.1528-1167.2010.02529.x. Epilepsia. 2010. PMID: 20394645 No abstract available.

• Classification concepts and terminology: is clinical description assertive and laboratory testing objective?

  Guerrini R. Guerrini R. Epilepsia. 2010 Apr;51(4):718-20. doi: 10.1111/j.1528-1167.2010.02530.x. Epilepsia. 2010. PMID: 20394646 No abstract available.

• A sound conceptual framework for an epilepsy classification is still lacking.

  Avanzini G. Avanzini G. Epilepsia. 2010 Apr;51(4):720-2. doi: 10.1111/j.1528-1167.2010.02531.x. Epilepsia. 2010. PMID: 20394647 No abstract available.

• Acute symptomatic seizures--should we retain the term?

  Shorvon S, Guerrini R. Shorvon S, et al. Epilepsia. 2010 Apr;51(4):722-3. doi: 10.1111/j.1528-1167.2010.02501.x. Epilepsia. 2010. PMID: 20394648 No abstract available.

• Proposed genetic classification of the "benign" familial neonatal and infantile epilepsies.

  Mulley JC, Heron SE, Dibbens LM. Mulley JC, et al. Epilepsia. 2011 Mar;52(3):649-50. doi: 10.1111/j.1528-1167.2010.02953.x. Epilepsia. 2011. PMID: 21395569 No abstract available.

Similar articles

• The new ILAE report on terminology and concepts for the organization of epilepsies: critical review and contribution.

  Panayiotopoulos CP. Panayiotopoulos CP. Epilepsia. 2012 Mar;53(3):399-404. doi: 10.1111/j.1528-1167.2011.03381.x. Epub 2012 Jan 13. Epilepsia. 2012. PMID: 22242702 Review.

• The new ILAE report on terminology and concepts for organization of epileptic seizures: a clinician's critical view and contribution.

  Panayiotopoulos CP. Panayiotopoulos CP. Epilepsia. 2011 Dec;52(12):2155-60. doi: 10.1111/j.1528-1167.2011.03288.x. Epub 2011 Oct 17. Epilepsia. 2011. PMID: 22004554 Review.

• The 2010 revised classification of seizures and epilepsy.

  Berg AT, Millichap JJ. Berg AT, et al. Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):571-97. doi: 10.1212/01.CON.0000431377.44312.9e. Continuum (Minneap Minn). 2013. PMID: 23739099 Free PMC article. Review.

• Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.

  Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Fisher RS, et al. Epilepsia. 2017 Apr;58(4):522-530. doi: 10.1111/epi.13670. Epub 2017 Mar 8. Epilepsia. 2017. PMID: 28276060

Cited by

• SPTAN1 encephalopathy: distinct phenotypes and genotypes.

  Tohyama J, Nakashima M, Nabatame S, Gaik-Siew C, Miyata R, Rener-Primec Z, Kato M, Matsumoto N, Saitsu H. Tohyama J, et al. J Hum Genet. 2015 Apr;60(4):167-73. doi: 10.1038/jhg.2015.5. Epub 2015 Jan 29. J Hum Genet. 2015. PMID: 25631096 Review.

• Combined targeted treatment in early onset epilepsy associated with tuberous sclerosis.

  Moavero R, Marciano S, Graziola F, Curatolo P. Moavero R, et al. Epilepsy Behav Case Rep. 2016 Jan 13;5:13-6. doi: 10.1016/j.ebcr.2015.12.001. eCollection 2016. Epilepsy Behav Case Rep. 2016. PMID: 27330989 Free PMC article.

• STXBP6 Gene Mutation: A New Form of SNAREopathy Leads to Developmental Epileptic Encephalopathy.

  Vinci M, Costanza C, Galati Rando R, Treccarichi S, Saccone S, Carotenuto M, Roccella M, Calì F, Elia M, Vetri L. Vinci M, et al. Int J Mol Sci. 2023 Nov 17;24(22):16436. doi: 10.3390/ijms242216436. Int J Mol Sci. 2023. PMID: 38003627 Free PMC article.

• Temporal lobe epilepsy semiology.

  Blair RD. Blair RD. Epilepsy Res Treat. 2012;2012:751510. doi: 10.1155/2012/751510. Epub 2012 Mar 7. Epilepsy Res Treat. 2012. PMID: 22957241 Free PMC article.

• Use of the International League Against Epilepsy (ILAE) 1989, 2010, and 2017 Classification of Epilepsy in children in a low-resource setting: A hospital-based cross-sectional study.

  Sharma S, Anand A, Garg D, Batra S, Mukherjee SB, Patra B, Aneja S. Sharma S, et al. Epilepsia Open. 2020 Jun 21;5(3):397-405. doi: 10.1002/epi4.12401. eCollection 2020 Sep. Epilepsia Open. 2020. PMID: 32913948 Free PMC article.

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information