Tautomerism in drug discovery - PubMed

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• PMID: 20490619
• DOI: 10.1007/s10822-010-9359-z

Tautomerism in drug discovery

Alan R Katritzky et al. J Comput Aided Mol Des. 2010 Jun.

Abstract

The influence of tautomerism on the precise structure of drugs and thus of their potential to interact with biological systems is discussed from thermodynamic and kinetic aspects. The types of tautomerism encountered in the structure of drugs in current use are surveyed together with the effect of pH, solvent polarity, and temperature.

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