Is the WKS motif the tissue-factor binding site for coagulation factor VII? - PubMed

Review

Is the WKS motif the tissue-factor binding site for coagulation factor VII?

B S Andrews. Trends Biochem Sci. 1991 Jan.

Abstract

Human tissue factor (TF), the membrane-bound glycoprotein receptor for the blood-clotting factor VII/VIIa, contains in its extracellular domain three repeats of the rare motif, tryptophan-lysine-serine (WKS). Murine tissue factor, which binds human factor VII/VIIa poorly, contains only one WKS motif suggesting that the WKS motif may be involved in the binding of human factor VII/VIIa to human TF. Sequence analysis has revealed a WKS motif in 23 human proteins, seven of which are involved in the coagulation process. Another five WKS-containing proteins share some functional properties with the coagulation proteins. Analysis of the properties of these proteins provides some insight into the possible functional role of the WKS motif.

Comment in

• WKS motifs and the cytokine receptor framework of tissue factor.

  Bazan JF. Bazan JF. Trends Biochem Sci. 1991 Sep;16(9):329. doi: 10.1016/0968-0004(91)90136-j. Trends Biochem Sci. 1991. PMID: 1835192 No abstract available.

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