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Early parietal response in episodic retrieval revealed with MEG - PubMed

Early parietal response in episodic retrieval revealed with MEG

Tyler M Seibert et al. Hum Brain Mapp. 2011 Feb.

Abstract

Recent neuroimaging and lesion studies have led to competing hypotheses for potential roles of the left lateral parietal lobe in episodic memory retrieval. These hypotheses may be dissociated by whether they imply a role in preretrieval or postretrieval processes. For example, one hypothesis is the left parietal cortex (particularly in more ventral subregions) forms part of an "episodic buffer" that supports the online representation of the retrieved target, a role that is, by definition, postretrieval. An alternate view maintains parietal activity (particularly in more dorsal subregions) contributes to top-down orientation of attention to retrieval search, a preretrieval role. The present investigation seeks to reveal the earliest onset of lateral parietal activity in three anatomically-defined subregions of the left lateral parietal cortex to identify any preretrieval activation. Subjects performed a pair-cued recall task while neural activity was recorded with magnetoencephalography (MEG) at millisecond temporal resolution. MEG data were then mapped to each subject's cortical surface using dynamic statistical parametric mapping (dSPM). Both dorsal and ventral regions showed retrieval-related activations beginning within ∼100 ms of the cue to retrieve and lasting up to 400 ms. We conclude that this early and transient pattern of activity in lateral parietal cortex is most consistent with a preretrieval role, possibly in directing attention to episodic memory retrieval.

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Figures

**Figure 1**
Pair‐cued recall task. Subjects viewed each pair for 3 s during the study phase (repeated in random order three times). MEG recordings were acquired during the test phase. In classify trials subjects made a simple living/nonliving judgment on the presented item. In recall‐classify trials subjects retrieved the absent associate and then made a living/nonliving judgment on the item in memory. In both conditions the test item was equally likely to appear on the left and right sides. The timeline at the bottom of the figure represents trial timing for the test phase. During the period of the timeline represented in black, the boxes and fixation cross were presented with both boxes in black. The cue period is enlarged only for display in the figure.

**Figure 2**
Three anatomical ROIs (A) on the left cortical surface and their estimated activity time courses (note baseline dSPM amplitude is ∼1.0) (B–D): Superior Parietal (green, B), Supramarginal (orange, C), Inferior Parietal (blue, D). Recall‐classify activity was significantly greater than classify activity for 100‐ms time period indicated in yellow; *: P < 0.01, **: P < 0.001, ***: P < 10⁻⁴, ****: P < 10⁻⁷ (P‐values from paired t‐tests).

**Figure 3**
Early retrieval‐related activity for left hemisphere. Baseline image is at −1,000 ms and is representative of the other images from the baseline period. Overlay shows the activity difference between recall‐classify (RC) and classify (C) conditions for baseline and from 150 to 230 ms following cue. Threshold was chosen for display purposes only; differences shown are >1.0 in dSPM amplitude.

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Early parietal response in episodic retrieval revealed with MEG - PubMed