Internal diversification of mitochondrial haplogroup R0a reveals post-last glacial maximum demographic expansions in South Arabia - PubMed

Internal diversification of mitochondrial haplogroup R0a reveals post-last glacial maximum demographic expansions in South Arabia

Viktor Cerný et al. Mol Biol Evol. 2011 Jan.

Abstract

Widespread interest in the first successful Out of Africa dispersal of modern humans ∼60-80 thousand years ago via a southern migration route has overshadowed the study of later periods of South Arabian prehistory. In this work, we show that the post-Last Glacial Maximum period of the past 20,000 years, during which climatic conditions were becoming more hospitable, has been a significant time in the formation of the extant genetic composition and population structure of this region. This conclusion is supported by the internal diversification displayed in the highly resolved phylogenetic tree of 89 whole mitochondrial genomes (71 being newly presented here) for haplogroup R0a-the most frequent and widespread haplogroup in Arabia. Additionally, two geographically specific clades (R0a1a1a and R0a2f1) have been identified in non-Arabic speaking peoples such as the Soqotri and Mahri living in the southern part of the Arabian Peninsula where a past refugium was identified by independent archaeological studies. Estimates of time to the most recent common ancestor of these lineages match the earliest archaeological evidence for seafaring activity in the peninsula in the sixth millennium BC.

Similar articles

• Population history of the Red Sea--genetic exchanges between the Arabian Peninsula and East Africa signaled in the mitochondrial DNA HV1 haplogroup.

  Musilová E, Fernandes V, Silva NM, Soares P, Alshamali F, Harich N, Cherni L, Gaaied AB, Al-Meeri A, Pereira L, Cerný V. Musilová E, et al. Am J Phys Anthropol. 2011 Aug;145(4):592-8. doi: 10.1002/ajpa.21522. Epub 2011 Jun 9. Am J Phys Anthropol. 2011. PMID: 21660931

• Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa.

  Quintana-Murci L, Semino O, Bandelt HJ, Passarino G, McElreavey K, Santachiara-Benerecetti AS. Quintana-Murci L, et al. Nat Genet. 1999 Dec;23(4):437-41. doi: 10.1038/70550. Nat Genet. 1999. PMID: 10581031

• High-resolution mtDNA studies of the Indian population: implications for palaeolithic settlement of the Indian subcontinent.

  Barnabas S, Shouche Y, Suresh CG. Barnabas S, et al. Ann Hum Genet. 2006 Jan;70(Pt 1):42-58. doi: 10.1111/j.1529-8817.2005.00207.x. Ann Hum Genet. 2006. PMID: 16441256

• Systematics of the lizard family pygopodidae with implications for the diversification of Australian temperate biotas.

  Jennings WB, Pianka ER, Donnellan S. Jennings WB, et al. Syst Biol. 2003 Dec;52(6):757-80. Syst Biol. 2003. PMID: 14668116

• Ice Ages and the mitochondrial DNA chronology of human dispersals: a review.

  Forster P. Forster P. Philos Trans R Soc Lond B Biol Sci. 2004 Feb 29;359(1442):255-64; discussion 264. doi: 10.1098/rstb.2003.1394. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15101581 Free PMC article. Review.

Cited by

• Inland post-glacial dispersal in East Asia revealed by mitochondrial haplogroup M9a'b.

  Peng MS, Palanichamy MG, Yao YG, Mitra B, Cheng YT, Zhao M, Liu J, Wang HW, Pan H, Wang WZ, Zhang AM, Zhang W, Wang D, Zou Y, Yang Y, Chaudhuri TK, Kong QP, Zhang YP. Peng MS, et al. BMC Biol. 2011 Jan 10;9:2. doi: 10.1186/1741-7007-9-2. BMC Biol. 2011. PMID: 21219640 Free PMC article.

• Mitochondrial haplogroup R offers protection against obesity in Kuwaiti and Qatari populations.

  Dashti M, Ali NM, Alsaleh H, John SE, Nizam R, Al-Mulla F, Thanaraj TA. Dashti M, et al. Front Endocrinol (Lausanne). 2024 Oct 11;15:1449374. doi: 10.3389/fendo.2024.1449374. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39464187 Free PMC article.

• Genomic Landscape of the Mitochondrial Genome in the United Arab Emirates Native Population.

  Aljasmi FA, Vijayan R, Sudalaimuthuasari N, Souid AK, Karuvantevida N, Almaskari R, Mohammed Abdul Kader H, Kundu B, Michel Hazzouri K, Amiri KMA. Aljasmi FA, et al. Genes (Basel). 2020 Aug 1;11(8):876. doi: 10.3390/genes11080876. Genes (Basel). 2020. PMID: 32752197 Free PMC article.

• Middle eastern genetic legacy in the paternal and maternal gene pools of Chuetas.

  Ferragut JF, Ramon C, Castro JA, Amorim A, Alvarez L, Picornell A. Ferragut JF, et al. Sci Rep. 2020 Dec 8;10(1):21428. doi: 10.1038/s41598-020-78487-9. Sci Rep. 2020. PMID: 33293675 Free PMC article.

• Projecting Ancient Ancestry in Modern-Day Arabians and Iranians: A Key Role of the Past Exposed Arabo-Persian Gulf on Human Migrations.

  Ferreira JC, Alshamali F, Montinaro F, Cavadas B, Torroni A, Pereira L, Raveane A, Fernandes V. Ferreira JC, et al. Genome Biol Evol. 2021 Sep 1;13(9):evab194. doi: 10.1093/gbe/evab194. Genome Biol Evol. 2021. PMID: 34480555 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Miscellaneous

  • NCI CPTAC Assay Portal