Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China - PubMed
- ️Fri Jan 01 2010
Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China
Xiuchan Guo et al. BMC Res Notes. 2010.
Abstract
Background: Southern China is a major area for endemic nasopharyngeal carcinoma (NPC). Genetic factors as well as environmental factors play a role in development of NPC. To investigate the roles of previously described carcinogen metabolism gene variants for NPC susceptibility in a Han Chinese population, we conducted a case-control study in two independent study population groups afflicted with NPC in Guangdong and Guangxi Provinces of southern China.
Methods: Five single nucleotide polymorphisms (SNPs) of CYP2E1-rs2031920, CYP2E1-rs6413432, GSTP1-rs947894, MPO-rs2333227 and NQO1-rs1800566 were genotyped by PCR-based RFLP, sequencing and TaqMan assay in 358 NPC cases and 629 controls (phase I cohort). Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI). To confirm our results, sixteen tag SNPs for GSTP1, MPO, NQO1 (which 100% covered these genes), and 4 functional SNPs of CYP2E1 were genotyped in another cohort of 213 NPC cases and 230 controls (phase II cohort).
Results: No significant associations in NPC risk were observed for the five polymorphisms tested in the phase I cohort. In an additional stratified analysis for phase I, there was no significant association between cases and controls in NPC high risk population (EBV/IgA/VCA positive population). Analysis of 14 tagging SNPs within the same genes in an independent phase II cohort were in agreement with no SNPs significantly associated with NPC.
Conclusions: Our results suggest that polymorphism of CYP2E1, GSTP1, MPO and NQO1 genes does not contribute to overall NPC risk in a Han Chinese in southern China.
Similar articles
-
Jia WH, Pan QH, Qin HD, Xu YF, Shen GP, Chen L, Chen LZ, Feng QS, Hong MH, Zeng YX, Shugart YY. Jia WH, et al. Carcinogenesis. 2009 Dec;30(12):2031-6. doi: 10.1093/carcin/bgp239. Carcinogenesis. 2009. PMID: 19805575 Free PMC article.
-
Rahman S, Yerizel E, Khambri D, Tjong DH. Rahman S, et al. Open Access Maced J Med Sci. 2019 Oct 14;7(20):3387-3390. doi: 10.3889/oamjms.2019.429. eCollection 2019 Oct 30. Open Access Maced J Med Sci. 2019. PMID: 32002057 Free PMC article.
-
[Association study of chromosome 4 STRs polymorphisms with nasopharyngeal carcinoma].
Guo XC, O'Brien SJ, Winkler C, Scott K, Hutcheson H, David V, Kessing B, Zheng YM, Liao J, Lui Y, Guy de T, Zeng Y. Guo XC, et al. Yi Chuan. 2006 Jul;28(7):783-90. Yi Chuan. 2006. PMID: 16825163 Chinese.
-
Sun P, Zhang Z, Wan J, Shao M. Sun P, et al. Wei Sheng Yan Jiu. 2007 Jan;36(1):11-5. Wei Sheng Yan Jiu. 2007. PMID: 17424838 Chinese.
-
Guo X, Winkler CA, Li J, Guan L, Tang M, Liao J, Deng H, de Thé G, Zeng Y, O'Brien SJ. Guo X, et al. Biomed Res Int. 2014;2014:434072. doi: 10.1155/2014/434072. Epub 2014 Aug 10. Biomed Res Int. 2014. PMID: 25180181 Free PMC article.
Cited by
-
Szeto CY, Lin CH, Choi SC, Yip TT, Ngan RK, Tsao GS, Li Lung M. Szeto CY, et al. FEBS Open Bio. 2014 Jan 13;4:128-40. doi: 10.1016/j.fob.2014.01.004. eCollection 2014. FEBS Open Bio. 2014. PMID: 24490137 Free PMC article.
-
Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population.
Hemissi I, Ayed H, Naimi Z, Meddeb K, Ayadi M, Zouari S, Zaghbib S, Talbi E, Chebil M, Ouerhani S. Hemissi I, et al. Mol Genet Genomic Med. 2021 Nov;9(11):e1819. doi: 10.1002/mgg3.1819. Epub 2021 Sep 22. Mol Genet Genomic Med. 2021. PMID: 34549902 Free PMC article.
-
de Oliveira RM, Figueiredo CVB, Santiago RP, Yahouédéhou SCMA, Carvalho SP, da Paz SS, Fiuza LM, de Miranda FN, da Guarda CC, Fonseca CA, Aleluia MM, Barbosa CG, Adorno EV, Gonçalves MS. de Oliveira RM, et al. Dis Markers. 2018 Aug 1;2018:9078939. doi: 10.1155/2018/9078939. eCollection 2018. Dis Markers. 2018. PMID: 30154939 Free PMC article.
-
Xu L, Yang M, Zhao T, Jin H, Xu Z, Li M, Chen H. Xu L, et al. Medicine (Baltimore). 2014 Dec;93(27):e178. doi: 10.1097/MD.0000000000000178. Medicine (Baltimore). 2014. PMID: 25501063 Free PMC article. Review.
-
Zhuo X, Song J, Liao J, Zhou W, Ye H, Li Q, Xiang Z, Zhang X. Zhuo X, et al. Medicine (Baltimore). 2016 Oct;95(43):e5156. doi: 10.1097/MD.0000000000005156. Medicine (Baltimore). 2016. PMID: 27787372 Free PMC article. Review.
References
-
- Wu JJ, Guo H, Su R. Analysis and forecast of incidence and mortality of nasopharynx cancer by time series in Zhongshan city. Chinese Journal of Hospital Statistics. 2001;8(1):16–19.
-
- Jia WH, Huang QH, Liao J, Ye W, Shugart YY, Liu Q, Chen LZ, Li YH, Lin X, Wen FL. Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China. BMC cancer. 2006;6:178. doi: 10.1186/1471-2407-6-178. - DOI - PMC - PubMed
-
- Guo XC, Scott K, Liu Y, Dean M, David V, Nelson GW, Johnson RC, Dilks HH, Lautenberger J, Kessing B. Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: study design, methods and feasibility. Hum Genomics. 2006;2(6):365–375. - PMC - PubMed
-
- Guo X, Johnson RC, Deng H, Liao J, Guan L, Nelson GW, Tang M, Zheng Y, de The G, O'Brien SJ. Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China. International journal of cancer. 2009;124(12):2942–2947. doi: 10.1002/ijc.24293. - DOI - PMC - PubMed
-
- Hiyama T, Yoshihara M, Tanaka S, Chayama K. Genetic polymorphisms and head and neck cancer risk (Review) Int J Oncol. 2008;32(5):945–973. - PubMed
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous